皮膚科学講座

愛知医科大学皮膚科学講座では，悪性腫瘍，膠原病，重症薬疹をはじめとする種々の難治性皮膚疾患から，アトピー性皮膚炎，蕁麻疹といったcommon skin diseasesの診療を行なうとともに，各種基礎，臨床研究を行ない，臨床，研究の両面から次世代をになう若い皮膚科医の育成を目指しています。

教室全体で若い医師の育成, 専門医・指導医の取得に向けて取り組んでいます。研修期間中は診療科の検討会には出席の義務があり，必要に応じ他科の検討会にも参加可能です。また，所属科責任指導者の指示下に，形成外科など他科の手術にも参加できます。

更に皮膚科専門医の綿密な連携のもと5年間の皮膚科後期研修プログラムを運用しています。このコースは終了時点で, 必ず皮膚科専門医を取得させるという明確な目的を持った研修です。

1. 皮膚ヘルペスウイルス感染症の研究では，PCR,LAMP法を用いた核酸診断法による感染症の診断，また皮膚疾患との関わりについての研究や名古屋大学との共同研究で単純ヘルペスウイルスを用いた腫瘍溶解療法(ウイルスによるがんの治療)の研究を行っています。
2. 多汗症および無汗症の臨床的研究では，イオントフォレーシス，ボツリヌス毒素局注などを用いた掌蹠多汗症の新しい治療法の開発の研究をしています。
3. 皮膚細胞外マトリックスの自然免疫における役割についての研究
4. アトピー性皮膚炎の臨床的研究では，漢方も取り入れた幅広い分野で最適な治療法を提供するための研究を行っています。

Phospholipase A2 from bee venom increases poly(I:C)-induced activation in human keratinocytes.
Nakashima A, Tomono S, Yamazaki T, Inui M, Morita N, Ichimonji I, Takagi H, Nagaoka F, Matsumoto M, Ito Y, Yanagishita T, Miyake K, Watanabe D, Akashi-Takamura S. Int Immunol. 2020 30;32:371-383.

SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation.
Takeichi T, Hirabayashi T, Miyasaka Y, Kawamoto A, Okuno Y, Taguchi S, Tanahashi K, Murase C, Takama H, Tanaka K, Boeglin WE, Calcutt MW, Watanabe D, Kono M, Muro Y, Ishikawa J, Ohno T, Brash AR, Akiyama M. J Clin Invest. 2020. 3;130:890-903.

Granulomatous pigmented purpuric dermatosis containing Propionibacterium acnes.
Takama H, Yanagishista T, Muto J, Ohshima Y, Takahashi E, Tsuzuki T, Uchida K, Eishi Y, Akiyama M, Watanabe D. Eur J Dermatol. 2018;28:540-542

Amenamevir, a novel helicase-primase inhibitor, for treatment of herpes zoster: A randomized, double-blind, valaciclovir-controlled phase 3 study.
Kawashima M, Nemoto O, Honda M, Watanabe D, Nakayama J, Imafuku S, Kato T, Katsuramaki T; study investigators. J Dermatol 2017;44:1219-1227.

Morphological analyses in fragility of pili torti with Björnstad syndrome.
Marubashi Y, Yanagishita T, Muto J, Taguchi N, Sugiura K, Kawamoto Y, Akiyama M, Watanabe D. J Dermatol. 2017

An actin-binding protein espin is a growth regulator for melanoma.
Yanagishita T, Yajima I, Kumasaka M, Iida M, Xiang L, Tamada Y, Matsumoto Y, Watanabe D, Kato M. J Invest Dermatol. 2014;134:2996-2999

Muto, J., Morioka , Y., Yamasaki, K., Kim, M., Garcia, A., Carlin, A.F., Varki, A., and Gallo, R.L.Hyaluronan digestion controls DC migration from the skin.
J Clin Invest. 2014;124:1309-1319.

Yanagishita T, Yajima I, Kumasaka M, Kawamoto Y, Tsuzuki T, Matsumoto Y, Watanabe D, Kato M. Actin-binding protein, Espin: a novel metastatic regulator for melanoma. Mol Cancer Res. 2014; 12: 440-6.

Ohshima Y, Yanagishita T, Ito K, Tamada Y, Nishimura N, Iwase S, Sugenoya J, Watanabe D. Treatment of patients with acquired idiopathic generalized anhidrosis.
Br J Dermatol. 2013; 168 : 430-2.

Bernard, J.J., Cowing-Zitron, C., Nakatsuji, T., Muehleisen, B., Muto, J., Borkowski, A.W., Martinez, L., Greidinger, E.L., Yu, B.D., and Gallo, R.L.Ultraviolet radiation damages self noncoding RNA and is detected by TLR3.Nat Med.2012;18:1286-1290.

Mizutani K, Akita Y, Yanagishita T, Kimura M, Tanaka T, Kinoshita Y, Nakano A, Tamada Y, Matsumoto Y, Watanabe D.
Comparison of the efficacy of ALA-PDT using an excimer-dye laser (630 nm) and a metal-halide lamp (600 to 740 nm) for treatment of Bowen's disease.
Photodermatol Photoimmunol Photomed. 2012; 28: 142-6.

Yanagishita T, Tamada Y, Ohshima Y, Ito K, Akita Y, Watanabe D.
Histological localization of aluminum in topical aluminum chloride treatment for palmar hyperhidrosis. J Dermatol Sci. 2012; 67: 69-71.

Ito K, Yanagishita T, Ohshima Y, Tamada Y, Watanabe D.
Therapeutic effectiveness of botulinum toxin type A based on severity of palmar hyperhidrosis. J Dermatol. 2011; 38: 859-63.

Thang ND, Yajima I, Kumasaka MY, Ohnuma S, Yanagishita T, Hayashi R, Shekhar HU, Watanabe D, Kato M.
Barium promotes anchorage-independent growth and invasion of human HaCaT keratinocytes via activation of c-SRC kinase. PLoS One. 2011; 6: e25636.

Nakano A, Watanabe D, Akita Y, Kawamura T, Tamada Y, Matsumoto Y.
Treatment efficiency of combining photodynamic therapy and ionizing radiation for Bowen's disease. J Eur Acad Dermatol Venereol. 2011; 25: 475-8.

Watanabe D.
Medical application of herpes simplex virus. J Dermatol Sci. 2010; 57: 75-82.

Nakano A, Tamada Y, Watanabe D, Ishida N, Yamashita N, Kuhara T, Yanagishita T, Kawamura C, Akita Y, Matsumoto Y.
A pilot study to assess the efficacy of photodynamic therapy for Japanese patients with actinic keratosis in relation to lesion size and histological severity.
Photodermatol Photoimmunol Photomed. 2009; 25: 37-40.

Kawada M, Tamada Y, Simizu H, Yanagishita T, Yamashita N, Ishida N, Watanabe D, Yoshida M, Ibi T, Sahashi K, Hashizume Y, Matsumoto Y.
Reduction in QSART and vasoactive intestinal polypeptide expression in the skin of Parkinson's disease patients and its relation to dyshidrosis. J Cutan Pathol. 2009; 36: 517-21.

Ohshima Y, Shimizu H, Yanagishita T, Watanabe D, Tamada Y, Sugenoya J, Tsuda T, Matsumoto Y.
Changes in Na+, K+ concentrations in perspiration and perspiration volume with alternating current iontophoresis in palmoplantar hyperhidrosis patients.
Arch Dermatol Res. 2008; 300: 595-600.

Watanabe D, Goshima F, Mori I, Tamada Y, Matsumoto Y, Nishiyama Y.
Oncolytic virotherapy for malignant melanoma with herpes simplex virus type 1 mutant HF10. J Dermatol Sci. 2008; 50: 185-96.

Kuhara T, Watanabe D, Akita Y, Takeo T, Ishida N, Nakano A, Yamashita N, Ohshima Y, Kawada M, Yanagishita T, Tamada Y, Matsumoto Y.
Thioredoxin upregulation by 5-aminolaevulinic acid-based photodynamic therapy in human skin squamous cell carcinoma cell line.
Photodermatol Photoimmunol Photomed. 2008; 24: 142-6.

Yanagishita T, Watanabe D, Akita Y, Nakano A, Ohshima Y, Tamada Y, Matsumoto Y.
Construction of novel in vitro epithelioid cell granuloma model from mouse macrophage cell line. Arch Dermatol Res. 2007; 299: 399-403.

Kuhara T, Yoshikawa T, Ihira M, Watanabe D, Tamada Y, Katano H, Asano Y, Matsumoto Y.
Rapid detection of human herpesvirus 8 DNA using loop-mediated isothermal amplification. J Virol Methods. 2007; 144: 79-85.

良き臨床医，研究医の育成

TEL

外線：0561-62-3311（代表）愛知医科大学　皮膚科学教室

内線：22161

FAX

0561-63-9914

E-mail

hifuka@aichi-med-u.ac.jp