薬理学講座

薬理学は『薬物をツールとして生体の調節機構を解明する』という特徴があるがゆえに,基礎生命科学の一分野であると同時に,臨床医学においても重要な位置を占める学問分野でもあります。学生には講義や実習を通じて『知識を智慧に換える薬理学の醍醐味』を伝えてゆきたいと考えています。そのためには,解剖学,生化学,生理学等で得た学習内容を基盤とし,学生が疾患の病態生理を十分に理解する必要があります。薬理学的な思考訓練が,学生の学習意欲の向上,独創的思考の醸成へ繋がることを期待しています。なお4年生の希望者に対して『ファーマコロジーを論じる会』を月1回程度開催しています。

教育方針

卒前教育においては,学生がプロトタイプとなる薬物の薬理作用を十分理解することによって薬理作用の原理原則を習得することに重点を置きます。これによって将来臨床現場で遭遇する新薬を含めた様々な薬物に柔軟に対応できるようにします。大学院教育においては,基礎・臨床を問わず広く研究者間の交流を深め,既存の知識を組み替えることによって,独創的な学際領域的研究の土壌を作りたいと考えております。

活動・研究内容

ストレス応答の基盤となる脳内機構の解析,特に視床下部室傍核の出力系の解析

スタッフ紹介

氏名 職名 専門分野
岡田 尚志郎 教授 神経科学
山口 奈緒子 准教授 神経科学
藤川 誠 助教 エネルギー代謝学
呉 煜秋 助教 天然物化学,神経科学
堀田 裕美 助手

研究テーマ

氏名 研究テーマ
岡田 尚志郎
  • ストレス応答の基盤となる脳内機構の解析,特に視床下部室傍核の出力系の解析
山口 奈緒子
  • ストレス応答の脳内調節機構の解明
藤川 誠
  • ストレス応答におけるエネルギー代謝調節機構の解明
呉 煜秋
  • ストレス応答の基盤となる脳内機構の解析,特に視床下部室傍核の出力系の解析

主な研究業績

論文

Yamamoto A, Matsumoto K, Hori K, Kameshima S, Yamaguchi N, Okada S, Okada M, Yamawaki H.
Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain.
Pflugers Arch 2020; 472, 673-681.

Tachi M*, Yamaguchi N*, Okada S.
(*The first two authors contributed equally to this work)
Thromboxane A2 in the paraventricular hypothalamic nucleus mediates glucoprivation-induced adrenomedullary outflow.
Eur J Pharmacol 2020; 875, 173034.

Hagihara M, Kuroki Y, Ariyoshi T, Higashi S, Fukuda K, Yamashita R, Matsumoto A, Mori T, Mimura K, Yamaguchi N, Okada S, Nonogaki T, Ogawa T, Iwasaki K, Tomono S, Asai N, Koizumi Y, Oka K, Yamagishi Y, Takahashi M, Mikamo H.
Clostridium butyricum modulates the microbiome to protect intestinal barrier function in mice with antibiotic-induced dysbiosis.
iScience 2020; 23, 100772.

Yamaguchi N, Mimura K, Okada S.
Prostaglandin E2 receptor EP3 subtype in the paraventricular hypothalamic nucleus mediates corticotropin-releasing factor-induced elevation of plasma noradrenaline levels in rats.
Eur J Pharmacol 2019; 863, 172693.

岡田尚志郎, 山口奈緒子.
ストレスによる血中カテコールアミン遊離・分泌の中枢性調節.
内分泌・糖尿病・代謝内科 2019; 49, 322-327.

Naoko Yamaguchi, Kaoru Mimura, Shoshiro Okada
GABAB receptors in the hypothalamic paraventricular nucleus mediate β-adrenoceptor-induced elevations of plasma noradrenaline in rats European Journal of Pharmacology, 2019; 848, 88-95.

Lin Y, Chen Y, Ukaji T, Okada S, Umezawa K.
Isolation of ketomycin from Actinomycetes as an inhibitor of 2D and 3D cancer cell invasion.
J Antibiot (Tokyo), 2019; 72, 148-154.

岡田尚志郎.
ストレスによる血中カテコールアミン遊離・分泌の中枢性調節機構.
自律神経 2019; 56, 248-251.

山口奈緒子, 岡田尚志郎.
CRFによる交感神経系活性化における視床下部室傍核アドレナリン受容体の役割.
自律神経 2018; 55, 295-300

Sano K., Morimoto C, Nakata M, Musatov S, Tsuda MC, Yamaguchi N, Sakamoto T, Ogawa S.
The role of estrogen receptor β in the dorsal raphe nucleus on the expression of female sexual behavior in C57BL/6J mice.
Front. Endocrinol. 9, 243

Okada S, Yamaguchi N.
Possible role of adrenoceptors in the hypothalamic paraventricular nucleus in corticotropin-releasing factor-induced sympatho-adrenomedullary outflow in rats. Auton Neurosci. 2017; 203, 74-80.

Ukaji T, Lin Y, Okada S, Umezawa K.
Inhibition of MMP-2-mediated cellular invasion by NF-κB inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis. Biochem Biophys Res Commun. 2017; 485(1), 76-81.

Sidthipong K, Ma J, Yu WL, Wang YF, Kobayashi S, Kishino S, Koide N, Yokochi T, Kato K, Okada S, Umezawa K.
Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor. Bioorg Med Chem Lett. 2017; 27(3), 562-566.

Yamaguchi N, Nakajima N, Okada S, Yuri K.
Effects of aging on stress-related responses of serotonergic neurons in the dorsal raphe nucleus of male rats. Neurobiology of Stress 2016; 3 43-51.

Nakata M, Sano K, Musatov S, Yamaguchi, N, Sakamoto T, Ogawa S.
Effects of Prepubertal or Adult Site-Specific Knockdown of Estrogen Receptor β in the Medial Preoptic Area and Medial Amygdala on Social Behaviors in Male Mice. eNeuro. 2016; 3(2).

Li J, Kandatsu N, Feng GG, Jiang JZ, Huang L, Kinoshita H, Okada S, Fujiwara Y.
Propofol reduces liver dysfunction caused by tumor necrosis factor-α production in Kupffer cells. J Anesth. 2016; 30(3):420-6

Ukaji T, Lin Y, Banno K, Okada S, Umezawa K.
Inhibition of IGF-1-Mediated Cellular Migration and Invasion by Migracin A in Ovarian Clear Cell Carcinoma Cells. PLoS One. 2015; 10(9):e0137663.

Kondo F, Tachi M, Gosho M, Fukayama M, Yoshikawa K, Okada S.
Changes in hypothalamic neurotransmitter and prostanoid levels in response to NMDA, CRF, and GLP-1 stimulation. Anal Bioanal Chem. 2015; 407(18):5261-72.

Ando K, Kondo F, Yamaguchi N, Tachi M, Fukayama M, Yoshikawa K, Gosho M, Fujiwara Y, Okada S.
Centrally administered isoproterenol induces sympathetic outflow via brain prostaglandin E2-mediated mechanisms in rats. 2015; 189: 1-7.

Yokoe N, Yamaguchi Y, Nishimura M, Tanaka H, Takahashi A, Baba K, Gosho M, Okada S.
UGT1A1*28 is associated with greater decrease in serum K+ levels following oral intake of procaterol. J Asthma. 2014; 10: 1-6.

Huang L, Kondo F, Gosho M, Feng GG, Harato M, Xia ZY, Ishikawa N, Fujiwara Y, Okada S.
Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells. PLoS One. 2014; 9(5): e98185.

Huang L, Kondo F, Harato M, Feng GG, Ishikawa N, Fujiwara Y, Okada S.
Enhanced expression of WD repeat-containing protein 35 via nuclear factor-kappa B activation in bupivacaine-treated Neuro2a cells. PLoS One. 2014;9(1): e86336.

Tachi M, Kondo F, Fukayama M, Yoshikawa K, Matsuura K, Okada S.
Mass spectrometric determination of prostanoids in rat hypothalamic paraventricular nucleus microdialysates. Auton Neurosci. 2014; 181: 49-54.

Yamaguchi N, Yuri K. Estrogen-dependent changes in estrogen receptor-beta; mRNA expression in middle-aged female rat brain. Brain Res. 2014; 11543: 49-57.

Tsuda MC, Yamaguchi N, Nakata M, Ogawa S.
Modification of female and male social behaviors in estrogen receptor beta knockout mice by neonatal maternal separation. Front Neurosci. 2014; 8: 274.

Kakinuma Y, Okada S, Nogami M, Kumon Y.
The human female heart incorporates glucose more efficiently than the male heart. Int j Cardiol. 2013; 168(3): 2518-21.

Rie Ishii, Satoshi Takatori, Kazuhiko Akatsu, Fumio Kondo, Hiroyuki Nakazawa, Tsunehisa Makino.
Determination of bisphenol A and 4-nonylphenol in media samples for in vitro fertilization by high-performance liquid chromatography with tandem mass spectrometry. Natural Science. 2013; 5: 541-548

Koji Tsunekawa, Fumio Kondo, Teruhiko Okada, Guo-Gang Feng, Lei Huang, Naohisa Ishikawa, Shoshiro Okada.
Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen speices generation and p38 mitogen-activated protein kinase activation. BMC Neuroscience. 2013; 14: 4.

Misako Harato, Lei Huang, Fumio Kondo, Koji Tsunekawa, Guo-Gang Feng, Jun-Hua Fan, Naohisa Ishikawa, Yoshihiro Fujiwara, Shoshiro Okada.
Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells. BMC Neuroscience. 2012; 13: 149.

Kakinuma Y, Okada S, Nogami M,Sano S,Kumon Y.
Systemic inflammation impairs cardiac glucose uptake. Int J Cardiol. 2012; 54 (2): 203-204.

Fan JH, Feng GG, Huang L, Tsunekawa K, Honda T, Katano Y, Hirooka Y, Goto H, Kandatsu N, Ando K, Fujiwara Y, Koide T, Okada S, Ishikawa N.
Role of naofen in apoptosis of hepatocytes induced by lipopolysaccharide through mitochondrial signaling in rats. Hepatol Res. 2012; 42(7): 696-705.

Takuma Higuchi, Shuji Sakamoto, Yoshihiko Kakinuma, Shoko Kai, Ken-ichi Yagyu, Hiroshi Todaka, Eunsup Chi, Shoshiro Okada, Takako Ujihara, Keiko Morisawa, Masafumi Ono, Yasunori Sugiyama, Waka Ishida, Atsuki Fukushima, Masayuki Tsuda, Yasutoshi Agata, Taketoshi Taniguchi.
High Expression of Nuclear Factor 90 (NF90) Leads to Mitochondrial Degradation in Skeletal and Cardiac Muscles. 2012; PLoS ONE 7(8): e43340.

Satoshi Takatori, Kazuhiko Akutsu, Fumio Kondo, Rie Ishii, Hiroyuki Nakazawa, Tsunehisa Makino.
Di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in media for in vitro fertilization. Chemosphere. 2012; 86: 454-9.

Fumio Kondo, Shoshiro Okada, Atsushi Miyachi, Miki Kurita, Kiyomi Tsuji, Ken-ichi Harada.
Microbial degradation of physiologically active peptides by strain B-9. Analytical Bioanalytical Chemistry. 2012; 403: 1783-91.

Koji Tsunekawa, Jun An, Lei Huang, Toshiaki Nonami, Tatsuro Koide, Fumio Kondo, Hiroshi Nishikawa, Tokutaro Miki, Satoru Sugiyama, Naohisa Ishikawa.
Effects of 1-O-hexyl-2, 3, 5-trimethylhydroquinone in Carbon Tetrachloride-induced Hepatic Apoptosis with a Possible Relationship to Naofen. International Journal of Pharmacology. 2012; 8(5): 434-439.

Kurokawa S, An J, Tsunekawa K, Shimomura Y, Kazama S, Ishikawa N, Nonami T, Sugiyama S.
Effect of L-arginine supplement on liver regeneration after partial hepatectomy in rats. World J Surg Oncol. 2012 May 31; 10(1): 99.

Yoshikazu Arai, Jun Ohgane, Shintaro Yagi, Rie Ito, Yusuke Iwasaki, Koichi Saito, Kazuhiko Akutsu, Satoshi Takatori, Rie Ishii, Rumiko Hayashi, Shun-Ichiro Izumi, Norihiro Sugino, Fumio Kondo, Masakazu Horie, Hiroyuki Nakazawa, Tsunehisa Makino, Kunio Shiota.
Epigenetic Assessment of Environmental Chemicals Detected in Maternal Peripheral and Cord Blood Samples. Journal of Reproduction and Development. 2011; 57: 507-517.

Ayako Kato, Jun Ueyama, Fumie Abe, Kazuo Hotta, IkutoTsukiyama, Taeyuki Ohshima, Fumio Kondo, Hiroko Saito, Takaaki Hasegawa.
Panipenem Does Not Alter the Pharmacokinetics of the Active Metabolite of Irinotecan SN-38 and Inactive Metabolite SN-38 Glucuronide (SN-38G) in Rats. Anticancer Research. 2011; 31: 2915-2922.

Orapin Wongsawatkul, Guo-Gang Feng, Chang Li, Lei Huang, Fumio Kondo, ShujiKurokawa, Yoshihiro Fujiwara and Naohisa Ishikawa.
Effects of Naofen on Enzyme Activities of Serine Proteases and Matrix Metallo-proteinases. International Journal of Pharmacology. 2011; 7(3): 388-393.

Okada S, Yamaguchi N.
Alpha1-adrenoceptor activation is involved in the central N-methyl-D-aspartate-induced adrenomedullary outflow in rats. Eur J Pharmacol. 2010; 640: 55-62.

Yamaguchi N, Ogawa S, Okada S.
Cyclooxygenase and nitric oxide synthase in the presympathetic neurons in the paraventricular hypothalamic nucleus are involved in restraint stress-induced sympathetic activation in rats. Neuroscience. 2010; 170: 773-781.

Fumio Kondo, Masanao Okumura, Hisao Oka, Hiroyuki Nakazawa, Shun-ichiro Izumi, Tsunehisa Makino.
Determination of Phthalates in Diet and Bedding for Experimental Animals Using Gas Chromatography-Mass Spectrometry. Bulletin of Environmental Contamination and Toxicology. 2010; 84: 212-216.

Fumio Kondo, Yoshitomo Ikai, Rumiko Hayashi, Masanao Okumura, Satoshi Takatori, Hiroyuki Nakazawa, Shun-ichiro Izumi, Tsunehisa Makino.
Determination of Five Phthalate Monoesters in Human Urine Using Gas Chromatography-Mass Spectrometry.Bulletin of Environmental Contamination and Toxicology. 2010; 85: 92-96.

Feng GG, Li C, Huang L, Tsunekawa K, Sato Y, Fujiwara Y, Komatsu T, Honda T, Fan JH, Goto H, Koide T, Hasegawa T, Ishikawa N.
Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis. Biochem Biophys Res Commun. 2010 Mar 26; 394(1):153-7.

Yuko Sato, Guo-Gang Feng, Lei Huang, Jun-Hua Fan, Chang Li, Jun An, Koji Tsunekawa, Shuji Kurokawa, Yoshihiro Fujiwara, Toru Komatsu, Fumio Kondo, Naohisa Ishikawa.
Enhanced expression of naofen in kidney of streptozotocin-induced diabetic rats: possible correlation to apoptosis of tubular epithelial cells. Clinical and Experimental Nephrology. 2010; 14(3): 205-12.

Jun An, Guo-Gang Feng, Lei Huang, Tsuyoshi Kurokawa, Toshiaki Nonami, Tatsuro Koide, Fumio Kondo, Toru Komatsu, Koji Tsunekawa, Yoshihiro Fujiwara, Hidemi Goto, Hiroshi Nishikawa, Tokutaro Miki, Satoru Sugiyama, Naohisa Ishikawa.
Effects of 1-O-hexyl-2,3,5-trimethylhydroquinone on carbon tetrachloride-induced hepatic cirrhosis in rats. Hepatology Research. 2010; 40(6): 566-73.

黒川修二, 黄磊, 馮国剛, 小松徹, 藤原祥裕, 近藤文雄, 石川直久.
腎尿細管上皮細胞のcaspase-3に対する高グルコースの影響と新規生理活性物質naofenの関与について--主としてphosphoinositide 3 kinase (PI3K)を介するcyclooxygenase-2 (COX-2)の活性化との関連について--.愛知医科大学医学会雑誌,2010年,Vol.38,55-59

Doisaki M, Katano Y, Nakano I, Hirooka Y, Itoh A, Ishigami M, Hayashi K, Goto H, Fujita Y, Kadota Y, Kitaura Y, Bajotto G, Kazama S, Tamura T, Tamura N, Feng GG, Ishikawa N, Shimomura Y.
Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease. Biochem Biophys Res Commun. 2010; 393: 303-307.

キーワード

ストレス,視床下部室傍核,プロスタノイド,神経科学,LC-MS

関連リンク


連絡先

所在地
〒480-1195 愛知県長久手市岩作雁又1番地1
TEL
外線:0561-62-3311(代表)愛知医科大学 医学部 薬理学講座
内線:12358
FAX
0561-63-1161
E-mail
sec2360@mail.aichi-med-u.ac.jp

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