薬理学講座

薬理学は，疾患機構に基づいて治療原理を体系化し，創薬戦略を理論的に構築する基盤科学です。分子生物学および構造生物学の進展により，医薬品開発は経験則中心の探索から，分子機構に立脚した設計科学へと転換しました。現在では，標的分子の構造情報とシステムレベルでの病態理解を統合することにより，高い特異性と安全性を備えた治療薬の設計が可能となっています。
医薬品は，低分子化合物に加え，抗体医薬，ペプチド医薬，核酸医薬へと多様化し，創薬概念そのものが再編されつつあります。本講座は，この変革期において，疾患理解と治療戦略を結ぶ理論基盤を確立し，次世代医療を支える新たな薬理学の構築を目指しています。
既存領域の延長にとどまらず，疾患概念の前提を問い直すことで，新たな治療原理の創出に取り組んでいます。

現在，臨床現場で使用可能な医薬品は15,000種類を超え，医療の高度化とともに薬物療法は複雑化しています。新薬や合剤，ジェネリック医薬品の増加により，薬剤理解の継続的な更新は不可欠となっています。
本講座では，薬理学を単なる知識の集積としてではなく，創薬を支える科学的原理とその歴史的展開を体系的に理解する学問として位置づけています。国際標準に基づく教育のもと，原理に立脚して思考し，自律的かつ批判的に判断できる臨床家および研究者の育成を目指しています。

外界刺激が生体の恒常性および病態形成に及ぼす影響を，分子・細胞・組織・個体の各階層にわたり統合的に解析しています。とくに，神経・免疫・内分泌系の動的相互作用に着目し，生命現象を横断する普遍的原理の抽出を目指しています。
その成果を基盤として，薬理学的手法により医学領域を横断的に再構築し，病態理解と治療戦略の新たな枠組みを提示しています。国際的研究動向と緊密に連動しつつ独自の研究領域を深化させ，本邦のみならず世界の薬理学研究を牽引する拠点の確立を目指しています。

1. Kondo T, Takayama Y, Kumagai Y, Takemura N, Hatakeyama S, Tominaga M, Maruyama K*.
   Bacterial extracellular vesicle ssRNA prevents colorectal cancer progression via Piezo1.
   Cell Rep 45: 116737, 2026.
2. Sakatani H, Konoa M, Hijiya M, Morita Y, Sumitomo T, Inukai T, Nakamura S, Koizumi Y, Maruyama K, Saika S, Murakami M, Hotomi M*.
   Trigeminal TRPV1 regulates pneumococcal nose-to-brain invasion via IL-6/TNF-α signals.
   mBio 16: e0133525, 2025.
3. Kondo T, Okada Y, Saika S, Yamaguchi N, Hatakeyama S, Maruyama K*.
   Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders.
   Eur J Cell Biol 103: 151418, 2024.
4. Lu YZ, Nayer B, Singh SK, Alshoubaki YK, Yuan E, Park AJ, Maruyama K, Akira S, Martino MM*.
   CGPR sensory neurons promote tissue healing via neutorphils and macrophages.
   Nature 628: 604-611, 2024.
5. Fujikawa M, Ueda M, Maruyama K*.
   Role of Kynurenine and its Derivatives in Neuroimmune System.
   Int J Mol Sci 25: 7144, 2024.
6. Miyamoto S, Takayama Y*, Kondo T, Maruyama K*.
   Senso-immunology: the hidden relationship between sensory system and immune system.
   J Bone Miner Metab 42: 413-420, 2024.
7. Gocho S*, Miyagi Y, Nakayama C, Miyachi Y, Okada S, Maruyama K, Oshima T.
   Comfort distance between patients and pharmacists during medication instruction: A prospective observational study at a cancer chemotherapy center.
   Neuropsychopharmacol Rep 44: 698-705, 2024.
8. Mikeli M, Fujikawa M*, and Tanabe T.
   GPD2: The Relationship with Cancer and Neural Stemness.
   Cells Dev 173: 203824, 2023.
9. Yamaguchi N*, Maruyama K, Okada S.
   Yokukansan, a Traditional Japanese Medicine, Suppresses Stress-Induced Sympathetic Activation via Central Responses in Rats.
   Nat Prod Commun 18, 2023.
10. Maruyama K*.
    Senso-immunology: The Emerging Connection between Pain and Immunity.
    Keio J Med 72: 77-87, 2023.
11. Miyamoto S, Kondo T, Maruyama K*.
    Senso-immunology: the past, present, and future.
    J Biochem 174: 305-315, 2023.
12. Sugisawa E#, Kondo T#, Kumagai Y, Kato H, Takayama Y, Isohashi K, Shimosegawa E, Takemura N, Hayashi Y, Sasaki T, Martino MM, Tominaga M, Maruyama K*.
    Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.
    Cell Rep 38: 110462, 2022.
13. Maruyama K*.
    Senso-immunology: crosstalk between nociceptive and immune systems.
    FEBS J 289: 4132-4145, 2022.
14. Okumo T*, Takayama Y*, Maruyama K*, Kato M, Sunagawa M*.
    Senso-Immunologic Prospects for Complex Regional Pain Syndrome Treatment.
    Front Immunol 12: 786511, 2022.
15. Maruyama K*, Kidoya H, Takemura N, Sugisawa E, Takeuchi O, Kondo T, Eid MMA, Tanaka H, Martino MM, Takakura N, Takayama Y, Akira S, Vandenbon A, Kumagai Y.
    Zinc finger protein St18 protects septic death by inhibiting VEGF-A from macrophages.
    Cell Rep 32: 107906, 2020.
16. Sugisawa E#, Takayama Y#, Takemura N#, Kondo T#, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M, Maruyama K*.
    RNA sensing by gut Piezo1 is essential for systemic serotonin synthesis.
    Cell 182: 609-624, 2020.
17. Ueda M, Matsuki T, Fukada M, Eda S, Toya A, Iio A, Tabata H, Nakayama A*.
    Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities.
    Mol Brain 13: 80, 2020.
18. Julier Z, Karami R, Nayer B, Lu YZ, Park AJ, Maruyama K, Kuhn GA, Muller R, Akira S, Martino MM*.
    Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling.
    Sci Adv 6: eaba7602, 2020.
19. Takayama Y*, Derouiche S*, Maruyama K*, Tominaga M*.
    Emerging Perspectives on Pain Management by Modulation of TRP Channels and ANO1.
    Int J Mol Sci 20: 3411, 2019.
20. Maruyama K*#, Takayama Y#, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M*.
    The ATP transporter VNUT mediates induction of Dectin-1-triggered Candida nociception.
    iScience 6: 306-318, 2018.
21. Islam S, Ueda M, Nishida E, Wang MX, Osawa M, Lee D, Itoh M, Nakagawa K, Nakagawa T*.
    Odor preference and olfactory memory are impaired in Olfaxin-deficient mice.
    Brain Res 1688: 81-90, 2018.
22. Larouche J, Sheoran S, Maruyama K, Martino MM*.
    Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets.
    Adv Wound Care 7: 209-231, 2018.
23. Maruyama K*, Takayama Y, Kondo T, Ishibashi KI, Sahoo BR, Kanemaru H, Kumagai Y, Martino MM, Tanaka H, Ohno N, Iwakura Y, Takemura N, Tominaga M, Akira S.
    Nociceptors Boost the Resolution of Fungal Osteo-inflammation via the TRP channel-CGRP-Jdp2 axis.
    Cell Rep 19: 2730-2742, 2017.
24. Maruyama K*, Takemura N, Martino MM, Kondo T, Akira S.
    Netrins as Prophylactic Targets of Skeletal diseases: A Double-Edged Sword?
    Pharmacol Res 122: 46-52, 2017.
25. Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S*.
    Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.
    Proc Natl Acad Sci USA 114: 7331-7340, 2017.
26. Sahoo BR, Maruyama K, Edula JR, Tougan T, Lin Y, Lee YH, Horii T, Fujiwara T*.
    Mechanistic and structural basis of bioengineered bovine Cathelicidin-5 with optimized therapeutic activity.
    Sci Rep 7: Article number 44781, 2017.
27. Lee MSJ, Maruyama K, Fujita Y, Konishi A, Lelliott PM, Itagaki S, Horii T, Lin J, Kahn S, Kuroda E, Akira S, Ishii KJ, Coban C*.
    Plasmodium products persist in the bone marrow and promote chronic bone loss.
    Sci Immunol 2: pii eaam8093, 2017.（Cover Picture）
28. Maruyama K*, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, Fujii T, Takemura N, Karuppuchamy T, Kondo T, Kawasaki T, Fukasaka M, Misawa T, Saitoh T, Suzuki Y, Martino MM, Kumagai Y, Akira S*.
    Bone-protective Functions of Netrin 1 Protein.
    J Biol Chem 291: 23854-23868, 2016.（Cover Picture）
29. Martino MM*, Maruyama K, Stanger S, Satoh T, Takeuchi O, Muller R, Akira S*.
    Inhibition of IL-1R1/MyD88 signaling promotes mesenchymal stem cell-driven tissue regeneration.
    Nat Commun 7: Article number 11051, 2016.
30. Kuroda Y, Maruyama K, Fujii H, Sugawara I, Ko SBH, Yasuda H, Matsui H, Matsuo K*.
    Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion.
    PLOS ONE 11: e0146544, 2016.
31. Ueda M, Li S, Itoh M, Wang MX, Hayakawa M, Islam S, Tana, Nakagawa K, Chen H, Nakagawa T*.
    Expanded polyglutamine embedded in the endoplasmic reticulum causes membrane distortion and coincides with Bax insertion.
    Biochem Biophys Res Commun 474: 259-263, 2016.
32. Maruyama K*, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino MM, Akira S*.
    5-azacytidine-induced protein 2 (AZI2) regulates bone mass by fine tuning osteoclast survival.
    J Biol Chem 290: 9377-9386, 2015.（Cover Picture）
33. Fujikawa M, Sugawara K, Tanabe T and Yoshida M*.
    Assembly of human mitochondrial ATP synthase through two separate intermediates, F1-c-ring and b-e-g complex.
    FEBS Lett 589: 2707-2712, 2015.
34. Maruyama K*, Akira S*.
    Emerging molecules in the interface between skeletal system and innate immunity.
    Pharmacol Res 99: 223-228, 2015.
35. Martino MM, Briquez PS, Maruyama K, Hubbell JA*.
    Extracellular matrix-inspired growth factor delivery systems for bone regeneration.
    Adv Drug Deliv Rev 94: 41-52, 2015.
36. Ueda M, Li S, Itoh M, Hayakawa-Yano Y, Wang MX, Hayakawa M, Hasebe-Matsubara R, Ohta K, Ohta E, Mizuno A, Hida Y, Matsumoto M, Chen H, Nakagawa T*.
    Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax.
    Biochem Biophys Res Commun 443: 1232-1238, 2014.
37. Fukasaka M, Ori D, Kawagoe T, Uematsu S, Maruyama K, Okazaki T, Kozaki T, Imamura T, Tartey S, Mino T, Satoh T, Akira S, Takeuchi O*.
    Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
    J Immunol 190: 5702-5711, 2013.
38. Maruyama K, Uematsu S, Kondo T, Martino MM, Kawasaki T, Akira S*.
    Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
    J Exp Med 210: 1947-1960, 2013.（Cover Picture）
39. Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S*, Kawai T.
    DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
    Proc Natl Acad Sci USA 110: 2969-2974, 2013.
40. Maruyama K, Fukasaka M, Vandenbon A, Saitoh T, Kawasaki T, Kondo T, Yokoyama KK, Kidoya H, Takakura N, Standley D, Takeuchi O, Akira S*.
    The transcription factor Jun dimerization protein 2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.
    Immunity 37: 1024-1036, 2012.
41. Maruyama K, Kawagoe T, Kondo T, Akira S*, Takeuchi O*.
    TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
    J Biol Chem 287: 29114-29124, 2012.
42. Fujikawa M, Imamura H, Nakamura J and Yoshida M*.
    Assessing Actual Contribution of IF1, Inhibitor of Mitochondrial FoF1, to ATP Homeostasis, Cell Growth, Mitochondrial Morphology, and Cell Viability.
    J Biol Chem 287: 18781-7, 2012.
43. Yamaguchi T, Takada Y, Maruyama K, Shimoda K, Arai Y, Nango N, Kosaki N, Takaishi H, Toyama Y, Matsuo K*.
    Fra-1/AP-1 Impairs Inflammatory Responses and Chondrogenesis in Fracture Healing.
    J Bone Miner Res 24: 2056-2060, 2009.
44. Maruyama K, Sano G, Ray N, Takada Y, Matsuo K*.
    c-Fos-deficient mice are susceptible to Salmonella enterica Serovar Typhimurium infection.
    Infect Immun 75: 1520-1523, 2007.
45. Sano G, Takada Y, Goto S, Maruyama K, Shindo Y, Oka K, Matsui H, Matsuo K*.
    Flagella Facilitate Escape of Salmonella from Oncotic Macrophages.
    J Bacteriol 189: 8224-8232, 2007.
46. Maruyama K, Takada Y, Ray N, Kishimoto Y, Penninger JM, Yasuda H, Matsuo K*.
    Receptor Activator of NF-κB Ligand and Osteoprotegerin Regulate Proinflammatory Cytokine Production in Mice.
    J Immunol 177: 3799-3805, 2006.
47. Ray N, Kuwahara M, Takada Y, Maruyama K, Kawaguchi T, Tsubone H, Ishikawa H, Matsuo K*.
    c-Fos suppresses systemic inflammatory response to endotoxin.
    Int Immunol 18: 671-677, 2006.
48. Maruyama K, Sano G, Matsuo K*.
    Murine osteoblasts respond to LPS and IFN-γ similarly to macrophages.
    J Bone Miner Metab 24: 454-460, 2006.

*corresponding author
#equally contribution

ストレス，感覚系，免疫系，骨格系，中枢神経系，末梢神経系

所在地

〒480-1195 愛知県長久手市岩作雁又１番地１

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外線：0561-63-1161

内線：12357

FAX

0561-63-1161

E-mail

sec2360※mail.aichi-med-u.ac.jp

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