薬理学講座

薬理学は，薬にまつわるあらゆる事象を扱う総合科学です。20世紀中頃まで，薬の開発は経験と勘に頼って行われてきましたが，近年になり，疾患特異性の高い安全で有効な薬を，科学的にデザインできるようになってきました。これに伴い，20年前までは薬といえば低分子化合物のことを指していたのが，現在では売上の約半数を抗体，ペプチド，核酸医薬が占めるようになり，医療現場では薬物治療のパラダイムシフトが進行しています。21世紀の薬理学は，物事をゼロベースで捉えることのできる人にとって，まさにフロンティアの大海原のようなものです。ペニシリンの同定に匹敵する未来の医療革新をもたらすのは，あなたかもしれません。

現在，薬理学の対象となる医師が処方できる薬は，1万5000種類にのぼります。幸いなことに，医療の細分化が進んだ現代では，一人の医師が日常的に使いこなすべき薬は数十種類ほどに限られます。しかし，新薬や合剤，ジェネリック医薬品が急増する昨今，医師が自ら扱う薬の特性を詳細に把握することは，ますます困難になっています。
ここで少し考えてみてください。100年前の薬の辞典を紐解けば，現代の科学的視点では到底受け入れがたい治療薬があふれかえっていることに気づくでしょう。これは，今日の最善が必ずしも未来の最善とは限らないことを意味しています。薬理学を単なる薬の博物学としてではなく，薬の開発にまつわる社会・歴史・経済的側面にも光をあてながら学ぶ学問と捉えるならば，将来，皆さんが次々と出現する未知の薬と対峙した際に，より洗練された批判的思考を発揮し，患者さんにとって最善の選択を導くことができるでしょう。文理融合による薬の学びと研究を通じて，皆さんの認知的複雑性の向上に貢献できれば，これに勝る喜びはありません。

外界からの刺激 （感覚刺激，感染，ストレスなど）が全身の生理的・病的状態に与える影響をさまざまな科学的手法を集学駆使することで明らかにしてゆきます。細分化された医学を統合することで新しい概念を創出し，本来の医学がもっている面白さを引き出します。

1. Kondo T, Okada Y, Saika S, Yamaguchi N, Hatakeyama S, Maruyama K*.
   Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders.
   Eur J Cell Biol 103:151418, 2024.
   
2. Lu YZ, Nayer B, Singh SK, Alshoubaki YK, Yuan E, Park AJ, Maruyama K, Akira S, Martino MM*.
   CGPR sensory neurons promote tissue healing via neutorphils and macrophages.
   Nature 628:604-611, 2024.
   
3. Fujikawa M, Ueda M, Maruyama K*.
   Role of Kynurenine and its Derivatives in Neuroimmune System.
   Int J Mol Sci 25:7144, 2024.
   
4. Miyamoto S, Takayama Y*, Kondo T, Maruyama K*.
   Senso-immunology: the hidden relationship between sensory system and immune system.
   J Bone Miner Metab 42:413-420, 2024.
   
5. Gocho S*, Miyagi Y, Nakayama C, Miyachi Y, Okada S, Maruyama K, Oshima T.
   Comfort distance between patients and pharmacists during medication instruction: A prospective observational study at a cancer chemotherapy center.
   Neuropsychopharmacol Rep 44:698-705, 2024
   
6. Mikeli M, Fujikawa M*, and Tanabe T.
   GPD2: The Relationship with Cancer and Neural Stemness.
   Cells Dev 173:203824, 2023.
   
7. Yamaguchi N*, Maruyama K, Okada S.
   Yokukansan, a Traditional Japanese Medicine, Suppresses Stress-Induced Sympathetic Activation via Central Responses in Rats.
   Nat Prod Commun 18, 2023.
   
8. Maruyama K*.
   Senso-immunology: The Emerging Connection between Pain and Immunity.
   Keio J Med 72:77-87, 2023.
   
9. Miyamoto S, Kondo T, Maruyama K*.
   Senso-immunology: the past, present, and future.
   J Biochem 174:305-315, 2023.
   
10. Sugisawa E#, Kondo T#, Kumagai Y, Kato H, Takayama Y, Isohashi K, Shimosegawa E, Takemura N, Hayashi Y, Sasaki T, Martino MM, Tominaga M, Maruyama K*.
    Nociceptor-derived Reg3γprevents endotoxic death by targeting kynurenine pathway in microglia.
    Cell Rep 38:110462, 2022.
    
11. Yamaguchi N, Kakinuma Y, Yakura T, Naito M, Okada S*.
    Glucose infusion suppresses acute restraint stress-induced peripheral and central sympathetic responses in rats.
    Auton Neurosci 239:102957, 2022.
    
12. Maruyama K*.
    Senso-immunology: crosstalk between nociceptive and immune systems.
    FEBS J 289:4132-4145. 2022.
    
13. Okumo T*, Takayama Y*, Maruyama K*, Kato M, Sunagawa M*.
    Senso-Immunologic Prospects for Complex Regional Pain Syndrome Treatment.
    Front Immunol 12:786511, 2022.
    
14. Maruyama K*, Kidoya H, Takemura N, Sugisawa E, Takeuchi O, Kondo T, Eid MMA, Tanaka H, Martino MM, Takakura N, Takayama Y, Akira S, Vandenbon A, Kumagai Y.
    Zinc finger protein St18 protects septic death by inhibiting VEGF-A from macrophages.
    Cell Rep 32:107906, 2020.
    
15. Sugisawa E#, Takayama Y#, Takemura N#, Kondo T#, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M, Maruyama K*.
    RNA sensing by gut Piezo1 is essential for systemic serotonin synthesis.
    Cell 182:609-624, 2020.
    
16. Ueda M, Matsuki T, Fukada M, Eda S, Toya A, Iio A, Tabata H, Nakayama A*.
    Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities.
    Mol Brain 13:80, 2020.
    
17. Julier Z, Karami R, Nayer B, Lu YZ, Park AJ, Maruyama K, Kuhn GA, Muller R, Akira S, Martino MM*.
    Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling.
    Sci Adv 6:eaba7602, 2020.
    
18. Yamaguchi N*, Mimura K, Okada S.
    Prostaglandin E2 receptor EP3 subtype in the paraventricular hypothalamic nucleus mediates corticotropin-releasing factor-induced elevation of plasma noradrenaline levels in rats.
    Eur J Pharmacol 863:172693, 2019.
    
19. Takayama Y*, Derouiche S*, Maruyama K*, Tominaga M*.
    Emerging Perspectives on Pain Management by Modulation of TRP Channels and ANO1.
    Int J Mol Sci 20:3411, 2019.
    
20. Maruyama K*#, Takayama Y#, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M*.
    The ATP transporter VNUT mediates induction of Dectin-1-triggered Candida nociception.
    iScience 6:306-318, 2018.
    
21. Islam S, Ueda M, Nishida E, Wang MX, Osawa M, Lee D, Itoh M, Nakagawa K, Nakagawa T*.
    Odor preference and olfactory memory are impaired in Olfaxin-deficient mice.
    Brain Res 1688:81-90, 2018.
    
22. Larouche J, Sheoran S, Maruyama K, Martino MM*.
    Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets.
    Adv Wound Care 7:209-231, 2018.
    
23. Maruyama K*, Takayama Y, Kondo T, Ishibashi KI, Sahoo BR, Kanemaru H, Kumagai Y, Martino MM, Tanaka H, Ohno N, Iwakura Y, Takemura N, Tominaga M, Akira S.
    Nociceptors Boost the Resolution of Fungal Osteo-inflammation via the TRP channel-CGRP-Jdp2 axis.
    Cell Rep 19: 2730-2742, 2017.
    
24. Maruyama K*, Takemura N, Martino MM, Kondo T, Akira S.
    Netrins as Prophylactic Targets of Skeletal diseases: A Double-Edged Sword?
    Pharmacol Res 122:46-52, 2017.
    
25. Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S*.
    Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.
    Proc Natl Acad Sci USA 114:7331-7340, 2017.
    
26. Sahoo BR, Maruyama K, Edula JR, Tougan T, Lin Y, Lee YH, Horii T, Fujiwara T*.
    Mechanistic and structural basis of bioengineered bovine Cathelicidin-5 with optimized therapeutic activity.
    Sci Rep 7: Article number 44781, 2017.
    
27. Lee MSJ, Maruyama K, Fujita Y, Konishi A, Lelliott PM, Itagaki S, Horii T, Lin J, Kahn S, Kuroda E, Akira S, Ishii KJ, Coban C*.
    Plasmodium products persist in the bone marrow and promote chronic bone loss.
    Sci Immunol 2:pii eaam8093, 2017. （Cover Picture）
    
28. Maruyama K*, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, Fujii T, Takemura N, Karuppuchamy T, Kondo T, Kawasaki T, Fukasaka M, Misawa T, Saitoh T, Suzuki Y, Martino MM, Kumagai Y, Akira S*.
    Bone-protective Functions of Netrin 1 Protein.
    J Biol Chem 291:23854-23868, 2016. （Cover Picture）
    
29. Yamaguchi N*, Nakajima N, Okada S, Yuri K.
    Effects of aging on stress-related responses of serotonergic neurons in the dorsal raphe nucleus of male rats.
    Neurobiol Stress 3:43-51, 2016.
    
30. Martino MM*, Maruyama K, Stanger S, Satoh T, Takeuchi O, Muller R, Akira S*.
    Inhibition of IL-1R1/MyD88 signaling promotes mesenchymal stem cell-driven tissue regeneration.
    Nat Commun 7:Article number 11051, 2016.
    
31. Kuroda Y, Maruyama K, Fujii H, Sugawara I, Ko SBH, Yasuda H, Matsui H, Matsuo K*.
    Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion.
    PLOS ONE 11:e0146544, 2016.
    
32. Ueda M, Li S, Itoh M, Wang MX, Hayakawa M, Islam S, Tana, Nakagawa K, Chen H, Nakagawa T*.
    Expanded polyglutamine embedded in the endoplasmic reticulum causes membrane distortion and coincides with Bax insertion.
    Biochem Biophys Res Commun 474:259-263, 2016.
    
33. Maruyama K*, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino MM, Akira S*.
    5-azacytidine-induced protein 2 （AZI2） regulates bone mass by fine tuning osteoclast survival.
    J Biol Chem 290:9377-9386, 2015. （Cover Picture）
    
34. Fujikawa M, Sugawara K, Tanabe T and Yoshida M*.
    Assembly of human mitochondrial ATP synthase through two separate intermediates, F1-c-ring and b-e-g complex.
    FEBS Lett 589:2707-2712, 2015.
    
35. Maruyama K*, Akira S*.
    Emerging molecules in the interface between skeletal system and innate immunity.
    Pharmacol Res 99:223-228, 2015.
    
36. Martino MM, Briquez PS, Maruyama K, Hubbell JA*.
    Extracellular matrix-inspired growth factor delivery systems for bone regeneration.
    Adv Drug Deliv Rev 94:41-52, 2015.
    
37. Ueda M, Li S, Itoh M, Hayakawa-Yano Y, Wang MX, Hayakawa M, Hasebe-Matsubara R, Ohta K, Ohta E, Mizuno A, Hida Y, Matsumoto M, Chen H, Nakagawa T*.
    Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax.
    Biochem Biophys Res Commun 443:1232-1238, 2014.
    
38. Fukasaka M, Ori D, Kawagoe T, Uematsu S, Maruyama K, Okazaki T, Kozaki T, Imamura T, Tartey S, Mino T, Satoh T, Akira S, Takeuchi O*.
    Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
    J Immunol 190:5702-5711, 2013.
    
39. Maruyama K, Uematsu S, Kondo T, Martino MM, Kawasaki T, Akira S*.
    Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
    J Exp Med 210:1947-1960, 2013. （Cover Picture）
    
40. Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S*, Kawai T.
    DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
    Proc Natl Acad Sci USA 110:2969-2974, 2013.
    
41. Maruyama K, Fukasaka M, Vandenbon A, Saitoh T, Kawasaki T, Kondo T, Yokoyama KK, Kidoya H, Takakura N, Standley D, Takeuchi O, Akira S*.
    The transcription factor Jun dimerization protein 2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.
    Immunity 37:1024-1036, 2012.
    
42. Maruyama K, Kawagoe T, Kondo T, Akira S*, Takeuchi O*.
    TRAF family member-associated NF-κB activator （TANK） is a negative regulator of osteoclastogenesis and bone formation.
    J Biol Chem 287:29114-29124, 2012.
    
43. Fujikawa M, Imamura H, Nakamura J and Yoshida M*.
    Assessing Actual Contribution of IF1, Inhibitor of Mitochondrial FoF1, to ATP Homeostasis, Cell Growth, Mitochondrial Morphology, and Cell Viability.
    J Biol Chem 287:18781-7, 2012.
    
44. Yamaguchi T, Takada Y, Maruyama K, Shimoda K, Arai Y, Nango N, Kosaki N, Takaishi H, Toyama Y, Matsuo K*.
    Fra-1/AP-1 Impairs Inflammatory Responses and Chondrogenesis in Fracture Healing.
    J Bone Miner Res 24: 2056-2060, 2009.
    
45. Maruyama K, Sano G, Ray N, Takada Y, Matsuo K*.
    c-Fos-deficient mice are susceptible to Salmonella enterica Serovar Typhimurium infection.
    Infect Immun 75:1520-1523, 2007.
    
46. Sano G, Takada Y, Goto S, Maruyama K, Shindo Y, Oka K, Matsui H, Matsuo K*.
    Flagella Facilitate Escape of Salmonella from Oncotic Macrophages.
    J Bacteriol 189:8224-8232, 2007.
    
47. Maruyama K, Takada Y, Ray N, Kishimoto Y, Penninger JM, Yasuda H, Matsuo K*.
    Receptor Activator of NF-κB Ligand and Osteoprotegerin Regulate Proinflammatory Cytokine Production in Mice.
    J Immunol 177:3799-3805, 2006.
    
48. Ray N, Kuwahara M, Takada Y, Maruyama K, Kawaguchi T, Tsubone H, Ishikawa H, Matsuo K*.
    c-Fos suppresses systemic inflammatory response to endotoxin.
    Int Immunol 18:671-677, 2006.
    
49. Maruyama K, Sano G, Matsuo K*.
    Murine osteoblasts respond to LPS and IFN-γ similarly to macrophages.
    J Bone Miner Metab 24:454-460, 2006.
    


*corresponding author
#equally contribution

ストレス，感覚系，免疫系，骨格系，中枢神経系，末梢神経系

所在地

〒480-1195 愛知県長久手市岩作雁又１番地１

TEL

外線：0561-63-1161

内線：12357

FAX

0561-63-1161

E-mail

sec2360※mail.aichi-med-u.ac.jp

  ※を半角@へ変更してください。