業績
2011
Konishi H, Mohseni M, Tamaki A, Garay JP, Croessmann S, Karnan S, Ota A, Wong HY, Konishi Y, Karakas B, Tahir K, Abukhdeir A, Gustin JP, Cidado J, Wang G, Cosgrove D, Cochran R, Jelovac D, Higgins M, Arena S, Lauring J, Gross A, Heaphy CM, Hosokawa Y, Gabrielson E, Meeker AK, Visvanathan K, Argani P,Bachman KE, Park BH: Mutation of a single BRCA1 allele leads to genomic instability in human breast epithelial cells. PNAS, 108, 17773-8, 2011.
Higgins MJ, Beaver JA, Wong HY, Gustin JP, Lauring JD, Garay JP, Konishi H, Mohseni M, Wang GM, Cidado J, Jelovac D, Cosgrove DP, Tamaki A, Abukhdeir AM and Park BH: PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells. Cancer Biol Ther, 11, 358-67, 2011.
Kagami Y, Karnan S, Nakagawa A, Oshiro K, Kato H, Koike K, Morishima Y, Seto M: Establishment of an Adult T-Cell Leukemia Cell Line (HU-ATTAK) Dependent for Proliferation on Human Umbilical Cord Vein Endothelial Cells. Open Leukemia Journal, 4, 1-8, 2011.
Sung CO, Kim SC, Karnan S, Karube K, Shin HJ, Nam DH, Suh YL, Kim SH, Kim JY, Kim SJ, Kim WS, Seto M, Ko YH: Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma. Blood, 117(4),1291-300. 2011.
Tumurkhuu G, Koide N, Hiwasa T, Ookoshi M, Dagvadorj J, Noman AS, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Yokochi T: ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun, 17, 97-105, 2011.
Haque A, Koide N, Iftakhar-E-Khuda I, Noman AS, Odkhuu E, Badamtseren B, Naiki Y, Komatsu T, Yoshida T, Yokochi T: Flavopiridol inhibits lipopolysaccharide-induced tumor necrosis factor-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway. Microbiol Immunol, 55, 160-7, 2011.
Badamtseren B, Odkhuu E, Koide N, Haque A, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T: Thalidomide inhibits interferon-gamma-mediated nitric oxide production in mouse vascular endothelial cells. Cell Immunol,270,19-24, 2011.
Haque A, Noman AS, Koide N, Odkhuu E, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T: An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide. Cancer Immunol Immunother, 60, 1439-46, 2011.
Kono T, Kashiwade Y, Asama T, Chisato N, Ebisawa Y, Yoneda M, Kasai S: Preventive effect of urinary trypsin inhibitor on the development of liver fibrosis in mice. Exp Biol Med (Maywood), 236(11), 1314-21, 2011.
Iida A, Konagaya T, Kaneko H, Funaki Y, Kanazawa T, Tokudome K, Hijikata Y, Masui R, Ogasawara N, Sasaki M, Yoneda M, Kasugai K: Usefulness of a slow nutrient drinking test for evaluating gastric perception and accommodation. Digestion, 84(4), 253-60, 2011.
Matsunaga M, Isowa T, Yamakawa K, Tsuboi H, Kawanishi Y, Kaneko H, Kasugai K, Yoneda M, Ohira H: Association between perceived happiness levels and peripheral circulating pro-inflammatory cytokine levels in middle-aged adults in Japan. Neuro Endocrinol Lett, 32(4), 458-63, 2011.
Handa T, Tsunekawa H, Yoneda M, Watanabe D, Mukai T, Yamamura M, Iwaki M, Zako M: Long-term remission of ocular and extraocular manifestations in Behçet’s disease using infliximab. Clin Exp Rheumatol, 29, S58-63, 2011.
Handa T, Tsunekawa H, Zako M: Cataract Surgery in Behçet’s Disease Patients One Week after Infliximab Administration. Case Rep Ophthalmol, 2, 176-8, 2011.
Imagama S, Sakamoto K, Tauchi R, Shinjo R, Ohgomori T, Ito Z, Zhang H, Nishida Y, Asami N, Takeshita S Sugiura N, Watanabe H, Yamashita T, Ishiguro N, Matsuyama Y, and Kadomatsu K: Keratan sulfate restricts neural plasticity after spinal cord injury. J. Neurosci., 31, 17091-17102, 2011.
Sugiura N, Setoyama Y, Chiba M, Kimata K, Watanabe H: Baculovirus envelope protein ODV-E66 is a novel chondroitinase with distinct substrate specificity. J Biol Chem. 286, 29026-29034,2011.
Levati L, Ruffini F, Muzi A, Umezawa K, Graziani Z, D’Atri S, Lacal P M: Placenta growth factor induces melanoma resistance to temozolomide through a mechanism that involves the activation of the transcription factor NF-κB. International J. Oncol, 38, 241-247, 2011.
Mino K, Ozaki M, Nakanishi K, Haga S, Sato M, Kina M, Takahashi M, Takahashi N, Kataoka A, Yanagihara K, Ochiya T, Kamiyama T, Umezawa K and Todo S: Inhibition of nuclear factor-kappaB suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion. Cancer Science, 102, 1052-1058, 2011.
Kobayashi K, Umezawa K and Yasui M: Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway. Biology of Reproduction, 84, 248-254, 2011.
梅澤一夫、須貝 威：新しいNF-B阻害剤DHMEQの生物有機化学と抗炎症・抗がん剤への展望。化学と生物, 49, 406-414, 2011.
Niitsu Y, Hakamata M, Goto Y, Higashi T, Shoji M, Sugai T and Umezawa K: Chemoenzymatic synthesis of (2R,3R,4R)-dehydroxymethylepoxyquinomicin (DHMEQ), a new activator of antioxidant transcription factor Nrf2. Org. Biomol. Chem, 9, 4635-4641, 2011.
Umezawa K: Possible role of peritoneal NF-B in peripheral inflammation and cancer: Lessons from the inhibitor DHMEQ. Biomedicine & Pharmacotherapy, 65, 252-259, 2011.
Hosoi H, Kawai N, Hagiwara H, Suzuki T, Nakazaki A, Takao K, Umezawa K and Kobayashi S: Synthesis and determination of the relative structure of akaterpin, a potent inhibitor of PI-PLC. Tetrahedron Letters, 52, 4961-4964, 2011.
Rapozzi V, Umezawa K and L. E. Xodo: Role of NF-B/Snail/RKIP loop in the response of tumor cells to photodynamic therapy. Lasers in Surgery and Medicine, 43, 575–585, 2011.
Isshiki M, Umezawa K and Tamura H: Coffee induces breast cancer resistance protein expression in Caco-2 cells. Biol. Pharm. Bull., 34, 1624-1627, 2011.
Suzuki E, Yamashita S and Umezawa K: Role of NF-κB in thyroid cancer. In A. Carpi and J. L. Mechanick eds. “Thyroid Cancer, from Emergent Biotechnologies to Clinical Practice Guidelines” CRC Press, pp 319-327, 2011.
Saitoh T, Takeiri M, Gotoh Y, Ishikawa Y, Umezawa K and Nishiyama S: Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-B components. Bioorganic & Medicinal Chemistry Letters, 21, 6293–6296, 2011.
Tsumura K, Suzuki A, Tsuzuki T, Kaneko H, Matsumura S, Imoto M, Umezawa K, Takahashi D and Toshima K: Molecular design, chemical synthesis, and biological evaluation of agents that selectively photo-degrade the transcription factor estrogen receptor-α. Org. Biomol. Chem., 9, 6357-6366, 2011.
Takeiri M, Tachibana M, Kaneda A, Ito A, Ishikawa Y, Nishiyama S, Goto R, Yamashita K, Shibasaki S, Hirokata G, Ozaki M, Todo S and Umezawa K: Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone. Inflammation Research, 60, 879-888, 2011.
McCubrey JA, SAbrams SL, Umezawa K, Cocco L, Martelli AM, Franklin RA, Chappell WH, Steelman LS: Novel approaches to target cancer initiating cells–Eliminating the root of the cancer. in Advances in Enzyme Regulation, 52(1), 249-64, 2011.
Kubota T and Umezawa K: Suppression of erosive arthritis by NF-κB Inhibitors.Current Rheumatology Reviews, 7, 275-281, 2011.
2012
Damdindorj L, Karnan S, Ota A, Takahashi M, Konish Y, Ekhtear Hossain, Hosokawa Y, and Konishi H: Assessment of the long-term transcriptional activity of a 550-bp-long human β-actin promoter region. Plasmid, 68, 195-200, 2012.
Konishi Y, Karnan S, Takahashi M, Ota A, Damdindorj L, Hosokawa Y, and Konishi H: A system for the measurement of gene targeting efficiency in human cell lines using an antibiotic resistance-GFP fusion gene. Biotechnique, 53, 141-152, 2012.
Karnan S, Konishi Y, Ota A, Takahashi M, Damdindorj L, Hosokawa Y, and Konishi H: Simple Monitoring of Gene Targeting Efficiency in Human Somatic Cell Lines Using the PIGA Gene. PLos One, 7, e47389, 2012.
Garay JP, Karakas B, Abukhdeir AM, Cosgrove DP, Gustin JP, Higgins MJ, Konishi H, Konishi Y, Lauring J, Mohseni M, Wang GM, Jelovac D, Weeraratna A, Sherman Baust CA, Morin PJ, Toubaji A, Meeker A, De Marzo AM, Lewis G, Subhawong A, Argani P and Park BH: The growth response to androgen receptor signaling in ERalpha-negative human breast cells is dependent on p21 and mediated by MAPK activation. Breast Cancer Res, 14, R27, 2012.
Fan JH, Feng GG, Huang L, Tsunekawa K, Honda T, Katano Y, Hirooka Y, Goto H, Kandatsu N, Ando K, Fujiwara Y, Koide T, Okada S, Ishikawa N: Role of naofen in apoptosis of hepatocytes induced by lipopolysaccharide through mitochondrial signaling in rats. Hepatol Res, 42 (7), 696-705, 2012.
Harato M, Huang L, Kondo F, Tsunekawa K, Feng GG, Fan JH, Ishikawa N, Fujiwara Y, Okada S: Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells. BMC Neurosci, 13 (1), 149, 2012.
Tsunekawa K, Kondo F, Huang L, Feng GG, Ishikawa N, Okada S: Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation. BMC Neurosci, 13 (1), 149, 2012.
Odkhuu E, Koide N, Haque A, Tsolmongyn B, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T: Inhibition of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine (PQQ). Immunol Lett , 142, 34-40, 2012.
TerashimaT, Haque A, Kajita Y, Takeuchi A, Nakagawa T, Yokochi T: Flavopiridol inhibits interferon-γ-induced nitric oxide production in mouse vascular endothelial cells. Immunol Lett, 148, 91-6, 2012.
Koide N, Morikawa A, Odkhuu E, Haque A, Badamtseren B, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Low susceptibility of NC/Nga mice to the lipopolysaccharide-mediated lethality with D-galactosamine sensitization and the involvement of fewer natural killer T cells. Innate Immun, 18, 35-43, 2012.
Yokochi T: A new experimental murine model for lipopolysaccharide-mediated lethal shock with lung injury. Innate Immun, 18, 364-70, 2012.
Kono T, Asama T, Chisato N, Ebisawa Y, Okayama T, Imai K, Karasaki H, Furukawa H, Yoneda M: Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats.Life Sci,90(3-4), 122-30, 2012.
Tamaki Y, Nakade Y, Yamauchi T, Makino Y, Yokohama S, Okada M, Aso K, Kanamori H, Ohashi T, Sato K, Nakao H, Haneda M, Yoneda M: Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis. J Gastroenterol. Aug 14, 2012.
Shigemura M, Nasuhara Y, Konno S, Shimizu C, Matsuno K, Yamaguchi E, Nishimura M: Effects of molecular structural variants on serum Krebs von den Lungen-6 levels in sarcoidosis. J Transl Med ,10, 111, 2012.
Gotou M, Hanamura I, Nagoshi H, Wakabayashi M, Sakamoto N, Tsunekawa N, Horio T, Goto M, Mizuno S, Takahashi M, Suganuma K, Yamamoto H, Hiramatsu A, Watarai M, Shikami M, Imamura A, Mihara H, Taki T, Miwa H, Taniwaki M, Nitta M : Establishment of a novel human myeloid leukemia cell line, AMU-AML1, carrying t(12;22)(p13;q11) without chimeric MN1-TEL and with high expression of MN1. Genes Chromosomes Cancer, 5, 42–53, 2012.
Koike A, Handa T, Zako M: Trabeculotomy in a Behçet’s Disease Patient One Week after Infliximab Administration. Case Rep Ophthalmol, 3 ,151-5, 2012.
Kono A, Oguri A, Yokoo K, Watanabe H: YAG laser treatment causes rapid degeneration and regeneration of collagen fibers in pig skin and facilitates fibroblast growth. J Plast Surg Hand Surg, 46, 308-312, 2012.
Hatano S, Kimata K, Hiraiwa N, Kusakabe M, Isogai Z, Adachi E, Shinomura T, Watanabe H: Versican/PG-M is essential for ventricular septal formation subsequent to atrioventricular cushion development. Glycobiology, 22, 1268-1277, 2012.
Ogawa H, Hatano S, Sugiura N, Nagai N, Sato T, Shimizu K, Narimatsu H, Kimata K, Watanabe H: Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development. PLoS ONE, 7, e43806, 2012.
Sugiura N, Shioiri T, Chiba M, Sato T, Narimatsu H, Kimata K, and Watanabe H: Construction of a chondroitin sulfate library with defined structures and analysis of molecular interactions. J.Biol.Chem. 287, 43390-43400, 2012.
Sobhany M, Kakuta Y, Sugiura N, Kimata K, and Negishi M: The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis J. Biol. Chem. 287, 36022-36028, 2012.
Kawaguchi Y, Sugiura N, Onishi M, Kimata K, Kimura M, and Kakuta Y: Crystallization and X-ray diffraction analysis of chondroitin lyase from baculovirus: envelope protein ODV-E66. Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun., 68, 190-192,2012.
Mori T, Kodera T, Yoshimine H, Kakuta Y, Sugiura N, Kimata K, and Okahata Y: Kinetics of iterative carbohydrate transfer to polysaccharide catalyzed by chondroitin polymerase on a highly sensitive flow-type 27 MHz quartz-crystal microbalance. Chem. Eur. J. , 18, 7388-7393, 2012.
Ota E, Takeiri M, Tachibana M, Ishikawa Y, Umezawa K and Nishiyama S: Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide. Bioorganic & Medicinal Chemistry Letters, 22, 164-167, 2012.
Fukushima T, Kawaguchi M, Yorita K, Tanaka H, Umezawa K and Kataoka H: Antitumor effect of dehydroxymethylepoxyquinomicin (DHMEQ), a small molecule inhibitor of nuclear factor-κB, on glioblastoma. Neuro-Oncology, 14, 19-28, 2012.
Arai Y, Iinuma H, Ikeda Y, Igarashi M, Hatano K, Kinoshita N, Ukaji T, Simizu S and Umezawa K: Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp. J. Antibiot, Dec 12. 2012.
Hosoi H, Kawai N, Hagiwara H, Suzuki T, Nakazaki A, Takao K, Umezawa K and Kobayashi S: Determination of the absolute structure of (+)-akaterpin. Chem. Pharm. Bull, 60, 137-143, 2012.
Saito R, Yamada S, Yamamoto Y, Kodera T, Hara A, Tanaka Y, Kimura F, Takei I, Umezawa K and Kojima I: Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats. Endocrinology, 153, 621-630, 2012.
Takeiri M, Horie K, Takahashi D, Watanabe M, Horie R, Simizu S ,and Umezawa K: Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB. Org. Biomol. Chem, 10, 3053-3059, 2012.
Funakoshi T, Yamashita K, Ichikawa N, Fukai M, Suzuki T, Goto R, Oura T, Kobayashi N, Katsurada T, Ichihara S, Ozaki M, Umezawa K, and Todo S : A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice. Journal of Crohn’s and Colotis, 6, 215-225, 2012.
Yasukagawa T, Niwa Y, Simizu S and Umezawa K: Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells. FEBS Lett, 1504–1509, 2012.
Noma N, Simizu S, Kambayashi Y, Kabe Y, Suematsu M, and Umezawa K: Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced breast cancer cell adhesion. Oncology Reports, 27, 2080-2084, 2012.
Niwa Y, Matsui C, Sukumwang N, Iinuma H, Ikeda Y, Koyano T, Kovitayakorn T, Simizu S and Umezawa K: Inhibition of lysenin-induced hemolysis by all-E-lutein derived from the plant Dalbergia latifolia. Planta Medica, 78, 957-961, 2012.
Kawata M, Koinuma D, Ogami T, Umezawa K, Iwata C, Watabe T ,Miyazono K: TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by proinflammatory cytokines derived from RAW 264.7 macrophage cells. J. Biochem, 151, 205-216, 2012.
Goto R, Yamashita K, Aoyagi T, Ueki S, Uno M, Oura T, Kobayashi N, Igarashi R, Shibasaki S, Wakayama K, Hirokata G, Shibata T, Umezawa K, Ozaki M,and Todo S: The immunomodulatory effect of nuclear factor-κB inhibition by dehydroxymethylepoxyquinomicin in combination with donor-specific blood transfusion. Transplantation, 93, 777-786, 2012.
Lampiasi N, Azzolina1 A, Umezawa K, Montalto G, J. A. McCubrey and Cervello M: The novel NF-κB inhibitor DHMEQ synergizes with Celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism. Cancer Lett, 322, 35-44, 2012.
Hinohara K, Kobayashi S, Simizu S, Tada K, Tsuji E, Nishioka K, Umezawa K, Mori M, Kanauchi H, Ogawa T, Inoue J, A. T and Gotoh N: ErbB/NFkB signaling controls self-renewal of breast cancer stem cells. Proc. Natl. Acad. Sci. USA, 109, 6584-6589, 2012.
Shimizu K, Konno S, Ozaki M, Umezawa K, Yamashita K, Todo S and Nishimura M: Dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, inhibits allergic inflammation and airway remodelling in murine models of asthma. Clin. Exp. Allergy, 42, 1273–1281, 2012.
Kaneda A, Gantsev S. K. and Umezawa K: Inhibition of cellular invasion and induction of anoikis in mouse melanoma cells by an anti-inflammatory agent DTCM-glutarimide. Creative Surgery and Oncology, 2012, 4-9, 2012.
Takeiri M, Ota E, Nishiyama S, Kiyota H, Simizu S ,and Umezawa K: Structure-activity relationship of 9-methylstreptimidone that induces selective apoptosis in adult T-cell leukemia cells. Oncology Res, 20, 7-14, 2012.
Brassesco MS, Pezuk JA, Morales AG, de Oliveira JC, Valera ET, da Silva GN, de Oliveira HF , Scrideli CA, Umezawa K, Tone LG: Cytostatic in vitro effects of DTCM-glutarimide on bladder carcinoma cells. Asian Pacific Journal of Cancer Prevention, 13, 1957-1962, 2012.
Nakayama M, Niki Y, Kawasaki T, Takeda Y, Horiuchi K, Sasaki A, Okada Y, Umezawa K, Ikegami H, Toyama Y and Miyamoto T: Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha. Arthritis Research & Therapy, 14, R120, 2012.
Alberti C, Pinciroli P, Valeri B, Ferri R, Ditto A, Umezawa K, Sensi M. L, Canevari S, and Tomassetti A: Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via NFκB pathway on advanced-stage epithelial ovarian cancer. Oncogene, 31, 4139-4149., 2012.
Castro-Gamero AM, Borges KS, da Silva Silveira V, Lira RC, de Paula Gomes Queiroz R, Valera FC, Scrideli CA, Umezawa K, Tone LG: Inhibition of nuclear factor-jB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells. Anti-Cancer Drugs, 2012, 638-650, 2012.
Valera FC, Umezawa K, Brassesco MS, Castro-Gamero AM, Queiroz RG, Scrideli CA, Tone LG, Anselmo-Lima WT: Suppression of inflammatory cytokine secretion by an NF-κB inhibitor in nasal polyps fibroblasts. Cellular Physiology and Biochemistry, 30, 13-22, 2012.
Kozakai N, Kikuchi E, Hasegawa M, Suzuki E, Ide H, Miyajima A, Horiguchi Y, Nakashima J, Umezawa K, Shigematsu N, and Oya M: Enhancement of radiosensitivity by a unique novel NF-kB inhibitor, DHMEQ, in prostate cancer. British J. Cancer, 107, 652-657, 2012.
Kobayashi R, Hanaya K, Shoji M, Umezawa K and Sugai T: A chemo-enzymatic expeditious route to racemic dihexanoyl (2R*,3R*,4R*)-dehydroxymethylepoxyquinomycin (DHMEQ), the precursor for lipase-catalyzed synthesis of the potent NF-kB Inhibitor, (2S,3S,4S)-DHMEQ. Chemical and Pharmaceutical Bulletin, 60, 1220-1223, 2012.
Niwa Y, Suzuki T, Dohmae N, Umezawa K and Simizu S: Determination of cathepsin V activity and intracellular trafficking by N-glycosylation. FEBS Lett, 586, 3601–3607, 2012.
2013
Takahashi M, Ota A, Karnan S, Hossain, Ekhtear, Konishi Y, Damdindorj L, Konishi H , Yokochi T, Nitta M, Hosokawa Y: Arsenic trioxide prevents nitric oxide production in LPS-stimulated RAW 264.7 by inhibiting a TRIF-dependent pathway. Cancer Science, 104, 165-170, 2013.
Hossain E, Ota A, Takahashi M, Karnan S, Damdindorj L, Konishi Y, Konishi H, Hosokawa Y: Arsenic Up-regulates the Expression of Angiotensin II Type I Receptor in Mouse Aortic Endothelial Cells;implications for molecular pathogenesis of arsenic-induced hypertension. Toxicology letter, 2013.in press
Wang GM, Wong HY, Konishi H, Blair BG, Abukhdeir A, Gustin JP, Rosen DM, Denmeade S, Rasheed Z, Matsui W, Garay JP, Mohseni M, Higgins MJ, Cidado J, Jelovac D, Croessmann S, Cochran R, Karnan S, Konishi Y, Ota A, Hosokawa Y, Argani P, Lauring J, Park BH: Single copies of mutant KRAS and mutant PIK3CA synergize in human epithelial cells to induce tumor formation. Cancer Research , Apr 11, 2013.
Komatsu T, Kido N, Sugiyama T, Yokochi T: Antiviral activity of acidic polysaccharides from Coccomyxa gloeobotrydiformi, a green alga, against an in vitro human influenza A virus infection. Immunopharmacol Immunotoxicol, 35, 1-7, 2012, 2013.
Mendjargar A, Odkhuu E, Koide N, Nagata H, Kurokawa T, Nonami T, Yokochi T: Pifithrin-α, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the MyD88-independent pathway. Int Immunophamacol. 15(4), 671-8, 2013.
Haque A, Koide N, Odkhuu E, Tsolmongyn B, Naiki Y, Komatsu T, Yoshida T, Yokochi T : Mouse pyrin and HIN domain family member 1 (pyhin1) protein positively regulates lipopolysaccharide-induced interferon-beta and nitric oxide production in macrophages. Innate Immun, 2013.in press.
Tanigawa T, Morikawa A, Hayashi K, Dan K, Tsuchihashi N, Goto F, Ueda H, Yokochi T: Auditory cells produce nitric oxide in response to bacterial lipopolysaccharide. Innate Immun, 19(2), 115-20 ,2013.
Tanaka H, Yamaguchi E, Fukuoka T, Ohbayasi Y, Sato M, Yokoi T: A case of disseminated nontuberculous mycobacteriosis and cerebellar toxoplasmosis with autoantibody to interferon-γ. Sarcoidosis Vasc Diffuse Lung Dis, 2013 . in press.
Miwa H, Shikami M, Goto M, Mizuno S, Takahashi M, Tsunekawa-Imai N, Ishikawa T, Mizutani M, Horio T, Gotou M, Yamamoto H, Wakabayashi M, Watarai M, Hanamura I, Imamura A, Mihara H, Nitta M : Leukemia cells show different metabolic perturbation provoked by 2-deoxyglucose. Oncology Reports ,29 ,2053-7 ,2013.
Sugita I, Yoneda M, Iwaki M, Zako M: Comparative analysis of hyaluronan’s affinity for antivascular endothelial growth factor agents. Ophthalmic Res,49,43-8, 2013.
Jinno-Oue J, Tanaka A, Shimize N, Mori T, Sugiura N, Kimata K, Isomura H, Hoshino H: Inhibitory effect of chondroitin sulfate type E on the binding step of human T-cell leukemia virus type 1. AIDS Res. Human Retrovirus. 29, 621-629, 2013.
Ichijo H, Sugiura N, Kimata K. Application of chondroitin sulfate derivatives for understanding axonal guidance in the nervous system during development. Polymers, 5, 254-268, 2013.
Shimbo M, Ando S, Sugiura N, Kimata K, and Ichijo H: Moderate repulsive effects of E-unit-containing chondroitin sulfate (CSE) on behavior of retinal growth cones. Brain Res. 1491, 34-43, 2013.
Shibasaki S, Yamashita K, Goto R, Wakayama K, Tsunetoshi Y, Zaitsu M, Igarashi R, Haga S, Ozaki M, Umezawa K ,and Todo S: Immunosuppressive Effects of DTCM-G, a Novel Inhibitor of the mTOR Downstream Signaling Pathway. Transplantation, 95(4), 542-50, 2013.
Suzuki K, Aiura K, Matsuda S, Itano O, Takeuchi O, Umezawa K, Kitagawa Y: Combined effect of dehydroxymethylepoxyquinomicin and gemcitabine in a mouse model of liver metastasis of pancreatic cancer. Clinical and Experimental Metastasis, 30(4), 381-92, 2013.
Nishimura M, Nii T, Trimova G, Miura S, Umezawa K, Ushiyama A, Kubota T: The NF-kB specific inhibitor DHMEQ prevents thrombus formation in a mouse model of anti-phospholipid syndrome. Journal of Nephropathology, 2013. in press.
Brassesco M. S, Roberto G, Morales A, J. de Oliveira, Delsin L. E, Pezuk J. A, Valera E. T, C. G. Carlotti Jr., E. M. Rego, H. F. de Oliveira, C. A. Scrideli, Umezawa K and L. G. Tone: Inhibition of NF-kB by Dehydroxymethylepoxyquinomicin suppresses invasion and synergistically potentiates Temozolomide and g-radiation cytotoxicity in glioblastoma cells. Chemotherapy Research and Practice, 2013, 593020, 2013.
特許・知財
発明者：杉浦信夫
名称：高硫酸化コンドロイチン硫酸類の合成方法、高硫酸化コンドロイチン硫酸類、および解析用試薬
出願：特願2011-18629 （2011年1月31日出願）
公開：特開2012-157271 （公開日2012年8月23日）
出願人：学校法人愛知医科大学
発明者：杉浦信夫
名称：コンドロイチン分解用またはコンドロイチン硫酸分解用の酵素、試薬、分解方法、高硫酸化オリゴ糖の製造方法、ならびに粗製物
出願：特願2012-6544（2012年1月16日出願）
（優先権出願）特願2011-18625 （2011年1月31日出願）
公開：特開2012-175969（公開日2012年9月13日）
出願人：学校法人愛知医科大学
