愛知医科大学 医学部 感染・免疫学講座２（旧寄生虫学）です。

免疫学分野業績

2026年

• Tomono, S., D. Narushima, M. Iwasaki, T. Yamaji, Y. Kasuga, S. Tsugane, N. Miyoshi, M. Kato, Y. Totsuka, M. Mutoh, H. Nakagama, T. Imai. 2026. Variations of blood concentration levels of reactive carbonyl species among three case-control studies of breast and colorectal cancer. Cancer Invest. In press.

2025年

• Biswas, M., S. Tomono, K. Kasai, H. Takagi, M. Inui, B. Basak, F. Nagaoka, T. Yamazaki, N. Morita, A. Okumura, and S. Akashi-Takamura. 2025. Enhanced lymphocyte infiltration in the liver of LDL receptor and Myeloid Differentiation 1 double knockout mice on high fat diet. Sci Rep 15(1):37077. 10.1038/s41598-025-21070-x
• 山崎達也，岩崎研太，伴野勧，髙村（赤司）祥子，抗ヒトRP105モノクローナル抗体はヒトB細胞を強力に活性化し、特異的抗体の産生レベルを増強する，日本エンドトキシン・自然免疫研究，2025年26巻p27-32

2024年

• Yamazaki, T., K. Iwasaki, S. Tomono, M. Imai, Y. Miwa, M. Shizuku, S. Ashimine, K. Ishiyama, M. Inui, D. Okuzaki, M. Okada, T. Kobayashi, and S. Akashi-Takamura. 2024. Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions. iScience 27(9), 10.1016/j.isci.2024.110649.
• Basak, B., and S. Akashi-Takamura. 2024. IRF3 function and immunological gaps in sepsis. Front Immunol 15:1336813. 10.3389/fimmu.2024.1336813.
• 伴野勧，髙村（赤司）祥子，ヨクイニンエキスによる免疫賦活作用，日本エンドトキシン・自然免疫研究，2024年25巻p59-62
• 山崎達也，髙村（赤司）祥子，抗体遺伝子を用いたウイルス感染症制御への挑戦，日本エンドトキシン・自然免疫研究，2024年24巻p1-8

2023年

• Chowdhury, S. I., M. Inui, T. Yamazaki, S. Tomono, H. Takagi, M. Biswas, S. I. Saitoh, K. Miyake, and S. Akashi-Takamura. 2023. The anti-TLR4 monoclonal antibody Sa15-21 enhances inflammatory cytokine production in LPS-stimulated macrophages. FEBS Lett 597:1246-1260. 10.1002/1873-3468.14619

2022年

• Biswas, M., T. Yamazaki, S. Tomono, S. Karnan, H. Takagi, I. Ichimonji, M. Inui, F. Nagaoka, Y. Hosokawa, and S. Akashi-Takamura. 2022. Cell surface expression of human RP105 depends on N-glycosylation of MD-1. FEBS Lett 596:3211-3231. 10.1002/1873-3468.14452.

2021年

• Kobayashi, A., Ito, A., Shirakawa, I., Tamura, A., Tomono, S., Shindou, H., Hedde, P. N., Tanaka, M., Tsuboi, N., Ishimoto, T., Akashi-Takamura, S., Maruyama, S., and Suganami, T., 2021. Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity. Front Immunol 12, 650856.
• Ariyoshi, T., Hagihara, M., Tomono, S., Eguchi, S., Minemura, A., Miura, D., Oka, K., Takahashi, M., Yamagishi, Y., Mikamo, H., 2021. Clostridium butyricum MIYAIRI 588 Modifies Bacterial Composition under Antibiotic-Induced Dysbiosis for the Activation of Interactions via Lipid Metabolism between the Gut Microbiome and the Host. Biomedicines., 9, 1065.
• Mure, K., Tomono, S., Mure, M., Horinaka, M., Mutoh, M., Sakai, T., Ishikawa, H., Wakabayashi, K., 2021. The Combination of Cigarette Smoking and Alcohol Consumption Synergistically Increases Reactive Carbonyl Species in Human Male Plasma. Int.J.Mol.Sci., 22, 9043.

2020年

• Yamazaki, T., Biswas, M., Kosugi K., Nagashima, M., Inui, M., Tomono, S., Takagi, H., Ichimonji, I., Nagaoka, F., Ainai A., Hasegawa, H., Chiba, J., Akashi-Takamura, S., 2020, A Novel Gene Delivery Vector of Agonistic Anti-Radioprotective 105 Expressed on Cell Membranes Shows Adjuvant Effect for DNA Immunization Against Influenza.  Front Immunol., 11, 606518.
• Biswas, M., Yamazaki, T., Chiba, J., Akashi-Takamura, S., 2020, Broadly Neutralizing Antibodies for Influenza: Passive Immunotherapy and Intranasal Vaccination. Vaccines (Basel) 8.
• Nakashima, A., Tomono, S., Yamazaki, T., Inui, M., Morita, N., Ichimonji, I., Takagi, H., Nagaoka, F., Matsumoto, M., Ito, Y., Yanagishita, T., Miyake, K., Watanabe, D., Akashi-Takamura, S., 2020. Phospholipase A2 from bee venom increases poly(I:C)-induced activation in human keratinocytes. Int Immunol 32, 371-383.
• Hagihara, M., Kuroki, Y., Ariyoshi, T., Higashi, S., Fukuda, K., Yamashita, R., Matsumoto, A., Mori, T., Mimura, K., Yamaguchi, N., Okada, S., Nonogaki, T., Ogawa, T., Iwasaki, K., Tomono, S., Asai, N., Koizumi, Y., Oka, K., Yamagishi, Y., Takahashi, M., Mikamo, H., 2020. Clostridium butyricum Modulates the Microbiome to Protect Intestinal Barrier Function in Mice with Antibiotic-Induced Dysbiosis. iScience, 23, 100772.

• Kurokawa, Y., Fujii, G., Tomono, S., Miyamoto, S., Hamoya, T., Takahashi, M., Narita, T., Komiya, M., Kobayashi, M., Higami, Y., Mutoh, M., 2020. The Radical Scavenger NZ-419 Suppresses Intestinal Polyp Development in Apc-Mutant Mice. J. Clin. Med., 9, 270.
• 髙村(赤司)祥子, ハチ毒由来PLA2の皮膚角化細胞における免疫応答への影響, 日本エンドトキシン・自然免疫研究, 2020年, 23, 34-38.

 

2019年

• Yamazaki, T., Inui, M., Hiemori, K., Tomono, S., Itoh, M., Ichimonji, I., Nakashima, A., Takagi, H., Biswas, M., Izawa, K., Kitaura, J., Imai, T., Sugiura, N., Tateno, H., Akashi-Takamura, S., 2019, Receptor-destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis. J Biol Chem 294, 6659-6669.
• Shimoyoshi, S., Takemoto, D., Ono, Y., Kitagawa, Y., Shibata, H., Tomono, S., Unno, K, Wakabayashi, K., 2019, Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice. Nutrients 12, 1582.
• Tatsuya Yamazaki, Sachiko Akashi-Takamura, Could a sugar chain on IgE be a new target for therapy for allergy?, Glycoforum, 2019, 22(5):A5.

　＊欧文版：https://www.glycoforum.gr.jp/article/22A15.html
　 ＊和文版：https://www.glycoforum.gr.jp/article/22A15J.html

• 山崎 達也, 高村(赤司)祥子, コレラ菌抽出物によるIgE の不活化とアナフィラキシーの抑制, 日本エンドトキシン・自然免疫研究, 2019年, 22, 72-78.
• 髙村(赤司)祥子, ハチ毒PLA2の機能と免疫応答への影響, 日本エンドトキシン・自然免疫研究, 2019年, 22, 79-82.

2018年

• Kusumoto, Y., Okuyama, H., Shibata, T., Konno, K., Takemoto, Y., Maekawa, D., Kononaga, T., Ishii, T., Akashi-Takamura, S., Saitoh, S.I., Ikebuchi, R., Moriya, T., Ueda, M., Miyake, K., Ono, S., Tomura, M., 2018, Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-alpha production. Cell Immunol 324, 33-41.
• Yamazaki, T., Nagashima, M., Ninomiya, D., Ainai, A., Fujimoto, A., Ichimonji, I., Takagi, H., Morita, N., Murotani, K., Hasegawa, H., Chiba, J., Akashi-Takamura, S., 2018, Neutralizing Antibodies Induced by Gene-Based Hydrodynamic Injection Have a Therapeutic Effect in Lethal Influenza Infection. Front Immunl 9,47.
• Yamazaki, T., Chiba, J., Akashi-Takamura, S., 2018, Neutralizing Anti-Hemagglutinin Monoclonal Antibodies Induced by Gene-Based Transfer Have Prophylactic and Therapeutic Effects on Influenza Virus Infection. Vaccines (Basel) 6.
• 山崎達也, 千葉丈, 高村(赤司)祥子,インフルエンザウイルス感染に対する中和抗体遺伝子を用いた治療法の検討, 日本エンドトキシン・自然免疫研究, 2018年, 21, 7-11.
• 髙村(赤司)祥子, 山崎達也, 森田奈央子, C4b-binding protein(C4BP)によるTLR応答制御機構, 日本エンドトキシン・自然免疫研究, 2018年, 21, 47-50.
• 山崎達也, 高村(赤司)祥子,【インフルエンザウイルス感染における免疫】上気道のインフルエンザウイルス感染における抗ヘマグルチニンIgG, IgA中和抗体の治療効果, 臨床免疫・アレルギー科, 2018年, 70(4), 331-338.

2017年

• Okamoto, N., Mizote, K., Honda, H., Saeki, A., Watanabe, Y., Yamaguchi-Miyamoto, T., Fukui, R., Tanimura, N., Motoi, Y., Akashi-Takamura, S., Kato, T., Fujishita, S., Kimura, T., Ohto, U., Shimizu, T., Hirokawa, T., Miyake, K., Fukase, K., Fujimoto, Y., Nagai, Y., Takatsu, K., 2017, Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex. J Biol Chem 292, 15378-15394.
• Iijima, J., Kobayashi, S., Kitazume, S., Kizuka, Y., Fujinawa, R., Korekane, H., Shibata, T., Saitoh, S.I., Akashi-Takamura, S., Miyake, K., Miyoshi, E., Taniguchi, N., 2017, Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling. Glycobiology 27, 1006-1015.
• Morita, N., Yamazaki, T., Murakami, Y., Fukui, R., Yamai, I., Ichimonji, I., Nakashima, A., Nagaoka, F., Takagi, H., Miyake, K., Akashi-Takamura, S., 2017. C4b-binding protein negatively regulates TLR4/MD-2 response but not TLR3 response. FEBS Lett 591, 1732-1741.
• 山崎 達也, 千葉 丈, 高村 祥子,【ウイルスに対する免疫反応】 インフルエンザウイルス感染に対する抗体・プラスミド療法, 臨床免疫・アレルギー科, 2017年, 68(1), 38-45.
• 一文字功, 髙村(赤司)祥子, 抗MD-1抗体による, 炎症反応における血清中MD-1の測定意義, 日本エンドトキシン・自然免疫研究, 2017年, 20, 50-53.

　免疫学分野過去の業績はこちら　

寄生虫学分野業績

2024年

• Nirmitha Lalindi De Silva; Viraji Nefertiti Hiromel De Silva; Mirani Vasanthamala Weerasooriya; Hidekazu Takagi; Makoto Itoh; Hirotomo Kato; Thishan Channa Yahathugoda. 2024. A real-time PCR for quantification of parasite burden and its correlations with clinical characteristics and anti-rKRP42 IgG level in cutaneous leishmaniasis in Sri Lanka. Parasitology international, 102865-102865 10.1016/j.parint.2024.102865.

2023年

• Akira Kawashima; Hidetoshi Nomoto; Hidekazu Takagi; Kayoko Hayakawa; Kanako Komaki-Yasuda; Shigeyuki Kano; Norio Ohmagari. 2023. Mansonella perstans infection in a Gabonese immigrant in Japan: an illustrative case of a clinical conundrum and management dilemma. Journal of travel medicine,30(7),10.1093/jtm/taad126

2022年

• Nirmitha Lalindi De Silva; Viraji Nefertiti Hiromel De Silva; Arachchige Theja Hemapala Deerasinghe; Upeksha Lakmini Rathnapala; Makoto Itoh; Hidekazu Takagi; Mirani Vasanthamala Weerasooriya; Hirotomo Kato; Thishan Channa Yahathugoda. 2022. Development of a Highly Sensitive Nested PCR and Its Application for the Diagnosis of Cutaneous Leishmaniasis in Sri Lanka. Microorganisms, 10(5) 10.3390/microorganisms10050990.
• Nirmitha Lalindi De Silva; Viraji Nefertiti Hiromel De Silva; Arachchige Theja Hemapala Deerasinghe; Upeksha Lakmini Rathnapala; Hirotomo Kato; Makoto Itoh; Hidekazu Takagi; Mirani Vasanthamala Weerasooriya; Thishan Channa Yahathugoda.2022. Validation of an In-House ELISA Method in the Diagnosis of Cutaneous Leishmaniasis Caused by Leishmania donovani in Hambantota District, Sri Lanka. Microorganisms, 10(5) 10.3390/microorganisms10050921
• Nguyen Quang Thieu; Vu Duc Chinh; Truong Van Hanh; Nguyen Van Dung; Hidekazu Takagi; Takeshi Annoura; Satoru Kawai; Gaku Masuda; Nguyen Van Tuan; Vu Viet Hung; Shusuke Nakazawa; Richard Culleton; Nguyen Thi Huong Binh; Yoshimasa Maeno.2022. Reduction in Plasmodium falciparum Pfk13 and pfg377 allele diversity through time in southern Vietnam. Tropical medicine and health, 50(1), 19-19,10.1186/s41182-022-00409-4

2021年

• Nagaoka, F., Yamazaki, T., Akashi-Takamura, S., and Itoh, M., 2021.  Detection of Urinary Antibodies and Its Application in Epidemiological Studies for Parasitic Diseases. Vaccines (Basel) 9.
• Manuel Calvopina, Carlos Bastidas-Caldes, Francisco Romero, Irina Villacres-Granda,  Jean-Pierre Pointier, Hidekazu Takagi, and Hiromu Sugiyama., 2021,Molecular Identification of the Human Pathogen Amphimerus sp. in the Freshwater Snail Aroapyrgus sp. in EcuadorAm. J. Trop. Med. Hyg., 00(00), pp. 1–7.
• Chihiro Horii, Hideharu Domoto, Hideki Orikasa, Hitoshi Sugiura, Seon-Hye Kim, Yoshimasa Maeno, Hidekazu Takagi and Yutaka Tsutsumi., 2021. Pseudoterranova Infestation Beneath Uterine Serosa J Clin Rev Case Rep, Volume 6 (4) 609-611.

2020年

• Kasahara, S., Ohari, Y., Jin, S., Calvopina, M., Takagi, H., Sugiyama, H., Itagaki, T., 2020. Molecular characterization revealed Fasciola specimens in Ecuador are all Fasciola hepatica, none at all of Fasciola gigantica or parthenogenic Fasciola species. Parasitol Int 80, 102215.
• Romero-Alvarez, D., Valverde-Munoz, G., Calvopina, M., Rojas, M., Cevallos, W., Kumazawa, H., Takagi, H., Sugiyama, H., 2020. Liver fluke infections by Amphimerus sp. (Digenea: Opisthorchiidae) in definitive and fish intermediate hosts in Manabi province, Ecuador. PLoS Negl Trop Dis 14, e0008286.

• Tanaka, T., Tokiwa, T., Hasegawa, H., Kadosaka, T., Itoh, M., Nagaoka, F., Maruyama, H., Mizuno, Y., Kanoh, H., Shirai, N., 2020. Morphologically and Genetically Diagnosed Dermal Dioctophyme Larva in a Chinese Man: Case Report. SN Comprehensive Clin Med 2, 467-471.

2019年

• Takagi, H., Yahathugoda, T.C., Tojo, B., Rathnapala, U.L., Nagaoka, F., Weerasooriya, M.V., Itoh, M., 2019, Surveillance of Wuchereria bancrofti infection by anti-filarial IgG4 in urine among schoolchildren and molecular xenomonitoring in Sri Lanka: a post mass drug administration study. Trop Med Health 47, 39.
• Chinh, V.D., Masuda, G., Hung, V.V., Takagi, H., Kawai, S., Annoura, T., Maeno, Y., 2019, Prevalence of human and non-human primate Plasmodium parasites in anopheline mosquitoes: a cross-sectional epidemiological study in Southern Vietnam. Trop Med Health 47, 9.
• Rahman, M.A., Yahathugoda, T.C., Tojo, B., Premaratne, P., Nagaoka, F., Takagi, H., Kannathasan, S., Murugananthan, A., Weerasooriya, M.V., Itoh, M., 2019, A surveillance system for lymphatic filariasis after its elimination in Sri Lanka. Parasitol Int 68, 73-78.

2018年

• Calvopina, M., Romero-Alvarez, D., Rendon, M., Takagi, H., Sugiyama, H., 2018, Hypolobocera guayaquilensis (Decapoda: Pseudothelphusidae): A New Crab Intermediate Host of Paragonimus mexicanus in Manabi Province, Ecuador. Korean J Parasitol 56, 189-194.
• 長岡史晃，鈴木純，高木秀和，山田南星，堀倫也，角坂照貴．2018, Clinostomum complanatumと同定された国内第２６例目の咽頭吸虫症．Clinical Parasitol　29(1), 49-52.
• 三島伸介，黒田友顯，中谷逸作，田淵幸一郎，下埜敬紀，神田靖士，西山利正，長岡史晃，伊藤誠，西村俊輝，倭正也，2018, 河島実花，繁冨明日香, 樫原雅美，野村明代，五十嵐裕子，中矢秀雄，米本隆浩．これまでに経験した疑診例を含むロア糸状虫症7 例の臨床的比較検討．Clinical Parasitol 29(1), 69-74.

2017年

• Fumiaki Nagaoka, Hidekazu Takagi, Eisei Noiri, Makoto Itoh. Antibody Capture Direct Agglutination Test (abcDAT) for Diagnosis of Visceral Leishmaniasis with Urine. Eisei Noiri, T.K. Jha. Kala Azar in South Asia Current Status and Sustainable Challenges(2^nd ed 2016). Switzerland: Springer. 2017:161-6.
• Bumpei Tojo, Makoto Itoh, Shyamal Kumar Paul, Mohammad Sohel Samad, Emi Ogasawara, Fumiaki Nagaoka, Dinesh Mondal, Rashidul Haque, Eisei Noiri. Geography and Reality of Kala-Azar Endemic in Bangladesh, Analysis Using GIS and Urine-Based Mass Screening. Eisei Noiri, T.K. Jha. Kala Azar in South Asia Current Status and Sustainable Challenges(2^nd ed 2016). Switzerland: Springer. 2017:271-86.

　寄生虫学分野過去の業績はこちら　

微生物学分野業績

2025年

• Kana Morinaga; Kohei Takahashi; Ryo Nagasawa; Wenzhi Tao; Shinya Sugimoto; Nozomu Obana; Nobuhiko Nomura; Andrew S Utada; Masanori Toyofuku.2025. Quorum sensing regulates a polysaccharide biosynthesis gene to control cell aggregation in Paracoccus denitrificans. ISME Communications, 10.1093/ismeco/ycaf198
• Wataru Kitagawa; Kensuke Igarashi; Ryo Nagasawa; Shigeyuki Kakizawa; Mizuki Horino; Kosuke Fujishima; Toshiaki Fukui; Souichiro Kato.2024. A promoter library for tuning gene expression in Cupriavidus necator under autotrophic conditions. Frontiers in Bioengineering and Biotechnology, 13, 10.3389/fbioe.2025.1595440
• Ryo Nagasawa; Tamami Ito; Chika Yamamoto; Mio Unoki; Nozomu Obana; Nobuhiko Nomura; Masanori Toyofuku.2025. Membrane vesicle production via cell-to-cell communication-induced autolysis in Streptococcus mutans. Microbiology Spectrum,10.1128/spectrum.00334-25
• Jun Arai; Akinori Okumura; Satoshi Kimoto; Kazumasa Sakamoto; Tomoya Kitada; Rena Kitano; Tadahisa Inoue; Sayaka Nishimura; Noriko Inden; Yukiko Muraki; Naoya Kato; Kiyoaki Ito. 2025. Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease. Hepatol. Int. 19:836-845 10.1007/s12072-025-10800-y

2023年

• Ryo Nagasawa; Nobuhiko Nomura; Nozomu Obana.2023. Identification of a Novel Gene Involved in Cell-to-cell Communication-induced Cell Death and eDNA Production in <i>Streptococcus mutans</i>.Microbes and Environments,  38(2), 10.1264/jsme2.me22085
• Kohei Takahashi; Xiaojie Li; Tatsuki Kunoh; Ryo Nagasawa; Norio Takeshita; Andrew S Utada. 2023. Novel Insights into Microbial Behavior Gleaned Using Microfluidics. Microbes and Environments 38(5)

2022年

• Yukie Tanaka; Naoko Morita; Yoshinori Kitagawa; Bin Gotoh; Takayuki Komatsu.2022. Human metapneumovirus M2-2 protein inhibits RIG-I signaling by preventing TRIM25-mediated RIG-I ubiquitination. Frontiers in Immunology, 13, 10.3389/fimmu.2022.970750
• Naoko Morita; Yukie Tanaka; Kenji Takeuchi; Yoshinori Kitagawa; Ryusuke Sakuma; Naoki Koide; Takayuki Komatsu.2022. SeV C Protein Plays a Role in Restricting Macrophage Phagocytosis by Limiting the Generation of Intracellular Double-Stranded RNA. Frontiers in Microbiology, 13,10.3389/fmicb.2022.780534