研究発表
論文発表(各論文はPubMedなど外部へリンクします)
- 2024年
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Mishima H, Ando S, Kuzuhara H, Yamamura A, Kondo R, Suzuki Y, Imaizumi Y, Yamamura H.
Melatonin inhibits voltage-gated potassium KV4.2 channels and negatively regulates melatonin secretion in rat pineal glands.
American Journal of Physiology: Cell Physiology, 327(4): C1023-C1034, 2024.
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Yamamura A, Fujiwara M, Kawade A, Amano T, Hossain A, Nayeem MJ, Kondo R, Suzuki Y, Inoue Y, Hayashi H, Suzuki S, Sato M, Yamamura H.
Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension.
European Journal of Pharmacology, 973: 176564, 2024.
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Shima N, Yamamura A, Fujiwara M, Amano T, Matsumoto K, Sekine T, Okano H, Kondo R, Suzuki Y, Yamamura H.
Up-regulated expression of two-pore domain K+ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension.
Frontiers in Cardiovascular Medicine 11: 1343804, 2024.
2023年
Ishida M, Yamamura A, Fujiwara M, Amano T, Ota M, Hikawa Y, Kondo R, Suzuki Y, Imaizumi Y, Yamamura H.
Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles.
Journal of Pharmacological Sciences 153(2): 84-88, 2023.
Kawade A, Yamamura A, Kondo R, Suzuki Y, Yamamura H.
Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling.
Journal of Pharmacological Sciences 151(2): 119-127, 2023.
2022年
Amano T, Yamamura A, Fujiwara M, Hirai S, Kondo R, Suzuki Y, Yamamura H.
Upregulated ClC3 channels/transporters elicit swelling-activated Cl- currents and induce excessive cell proliferation in idiopathic pulmonary arterial hypertension.
Biological & Pharmaceutical Bulletin 45(11): 1684-1691, 2022.
Miyaki R*, Yamamura A*, Kawade A, Fujiwara M, Kondo R, Suzuki Y, Yamamura H.
SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells.
Biochemical and Biophysical Research Communications 607: 44-48, 2022.
(* equally contributed)
Nayeem MJ, Yamamura A, Hayashi H, Muramatsu H, Nakamura K, Sassa N, Sato M.
Imatinib mesylate inhibits androgen-independent PC-3 cell viability, proliferation, migration, and tumor growth by targeting platelet-derived growth factor receptor-α.
Life Science 288: 120171, 2022.
2021年
Kawade A, Yamamura A, Fujiwara M, Kobayashi S, Mori S, Horii C, Hiraku A, Suzumura S, Tsukamoto K, Ohara N, Kondo R, Suzuki Y, Yamamura H.
Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats.
Journal of Pharmacological Sciences 147(1):81-85, 2021.
Sato Maki, Hayashi H, Kanikowska D.
Seasonal differences in clock gene expression levels in buccal epithelial cells of obese men: a pilot study.
International Journal of Biometeorology 65(7): 1119-1124, 2021.
Yamamura A, Nayeem J, Muramatsu H, Nakamura K, Sato M.
MAZ51 blocks the tumor growth of prostate cancer by inhibiting vascular endothelial growth factor receptor 3.
Frontiers in Pharmacology 12:667474, 2021.
Hiraishi K, Kurahara LH, Feng J, Yamamura A, Cui Y, Yahiro E, Yokomise H, Go T, Ishikawa K, Yokota N, Fujiwara A, Onitsuka M, Abe K, Ohga S, Satoh T, Okada Y, Yue L, Inoue R, Hirano K.
Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension.
Translational Research: The Journal of Laboratory and Clinical Medicine 233: 127-143, 2021.
Yamamura A, Nayeem MJ, Sato M.
The Rho kinase 2 (ROCK2)-specific inhibitor KD025 ameliorates the development of pulmonary arterial hypertension.
Biochemical and Biophysical Research Communications 534: 795-801, 2021.
2020年
Mamun AA, Hayashi H, Yamamura A, Nayeem MJ, Sato M.
Hypoxia induces the translocation of glucose transporter 1 to the plasma membrane in vascular endothelial cells.
Journal of Physiological Sciences 70(1):44, 2020.
Kurahara LH, Hiraishi K, Yamamura A, Zhang Y, Abe K, Yahiro E, Aoki M, Koga K, Yokomise H, Go T, Ishikawa K, Bo Z, Kishi H, Kobayashi S, Aoki-Shoi N, Toru S, Inoue R, Hirano K
Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.
Journal of Molecular and Cellular Cardiology 148: 50-62, 2020.
Iwase S, Nishimura N, Tanaka K, Mano T.
Effects of microgravity on human physiology.
In: Beyond LEO - Human Health Issues for Deep Space Exploration (ed: Reynolds RJ), IntechOpen, 2020. Review.
Babicheva A, Ayon RJ, Zhao T, Ek Vitorin JF, Pohl NM, Yamamura A, Yamamura H, Quinton BA, Ba M, Wu L, Ravellette KS, Rahimi S, Balistrieri F, Harrington A, Vanderpool RR, Thistlethwaite PA, Makino A, Yuan JX.
MicroRNA-mediated Downregulation of K+ Channels in Pulmonary Arterial Hypertension.
American Journal of Physiology: Lung Cellular and Molecular Physiology 318(1): L10-L26, 2020.
2019年
Minakata T, Inagaki A, Yamamura A, Yamamura H, Sekiya S, Murakami S.
Calcium-sensing receptor is functionally expressed in the cochlear perilymphatic compartment and essential for hearing.
Frontiers in Molecular Neuroscience 12:175, 2019.
Inukai Y.
Possible compensatory mechanisms of segmental and unilateral hyperhidrosis: estimation based on the efferent phase of the physiological mechanism of the skin pressure-sweating reflex.
The Autonomic Nervous System (自律神経) 56(1): 25-32, 2019. Review.
Yamamura A, Nayeem MJ, Mamun AA, Takahashi R, Hayashi H, Sato M.
Platelet-derived growth factor up-regulates Ca2+-sensing receptors in idiopathic pulmonary arterial hypertension.
FASEB Journal 33(6): 7363-7374, 2019.
Yamamura A, Nayeem MJ, Sato M.
Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells.
Journal of Pharmacological Sciences 139(3): 254-257, 2019.
Hayashi H, Mamun AA, Takeyama M, Yamamura A, Zako M, Yagasaki R, Nakahara T, Kamei M, Sato M.
Activator of G-protein signaling 8 is involved in VEGF-induced choroidal neovascularization.
Scientific Reports 9(1): 1560, 2019.
Nishimura R, Nishimura N, Iwase S, Takeshita M, Katashima M, Katsuragi Y, Sato M.
Effects of catechin-enriched ion beverage intake on thermoregulatory function in a hot environment.
Journal of Physiological Sciences 69(1): 39-45, 2019.
2018年
Sakima M, Hayashi H, Mamun AA, Sato M.
VEGFR-3 signaling is regulated by a G-protein activator, activator of G-protein signaling 8, in lymphatic endothelial cells.
Experimental Cell Research 368(1): 13-23, 2018.
Nakakaji R, Umemura M, Mitsudo K, Kim J-H, Hoshino Y, Sato I, Masuda T, Yamamoto M, Kioi M, Koizumi T, Fujita T, Yokoyama U, Iida M, Sato M, Sato H, Murofushi S, Shibata S, Aoki I, Eguchi H, Tohnai I, Ishikawa Y.
Treatment of oral cancer using magnetized paclitaxel.
Oncotarget 9(21): 15591-15605, 2018.
Suita K, Fujita T, Cai W, Hidaka Y, Jin H, Prajapati R, Umemura M, Yokoyama U, Sato M, Knollmann BC, Okumura S, Ishikawa Y.
Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice.
Pflugers Archiv: European Journal of Physiology 470(6): 923-935, 2018.
Jin H, Fujita T, Jin M, Kurotani R, Hidaka Y, Cai W, Suita K, Prajapati R, Liang C, Ohnuki Y, Mototani Y, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y.
Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.
Journal of Physiological Sciences 68: 77-87, 2018.
2017年
Umemura M, Kim JH, Aoyama H, Hoshino Y, Fukumura H, Nakakaji R, Sato I, Ohtake M, Akimoto T, Narikawa M, Tanaka R, Fujita T, Yokoyama U, Taguri M, Okumura S, Sato M, Eguchi H, Ishikawa Y.
The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity.
Journal of Pharmacological Sciences 134(4): 203-210, 2017.
Kinoshita H, Watanabe K, Azma T, Feng G-G, Akahori T, Hayashi H, Sato M, Fujiwara Y, Wakatsuki A.
Human serum albumin and oxidative stress in preeclamptic women and the mechanism of albumin for stress reduction.
Heliyon 3(8): e00369, 2017.
Jin H, Fujita T, Jin M, Kurotani R, Namekata I, Hamaguchi S, Hidaka Y, Cai W, Suita K, Ohnuki Y, Mototani Y, Shiozawa K, Prajapati R, Liang C, Umemura M, Yokoyama U, Sato M, Tanaka H, Okumura S, Ishikawa Y.
Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway.
Journal of Molecular and Cellular Cardiology 108: 170-180, 2017.
Yamamura A, Fujitomi E, Ohara N, Tsukamoto K, Sato M, Yamamura H.
Tadalafil induces antiproliferation, apoptosis, and phosphodiesterase type 5 downregulation in idiopathic pulmonary arterial hypertension in vitro.
European Journal of Pharmacology 810: 44-50, 2017.
Sato Maki, Wakamura T, Morita T, Okamoto A, Akashi M, Matsui T, Sato Motohiko
Effects of bright light exposure during daytime on peripheral clock gene expression in humans.
International Journal of Biometeorology 61(6):1133-1138, 2017.
Iwase S, Nishimura N, Kuwahara Y, Sugenoya J.
Skin sympathetic nerve activity and thermoregulatory control in humans.
In: Clinical Assessment of the Autonomic Nervous System (Iwase S, Hayano J, Orimo S eds). Springer Japan, pp. 47-71, 2017. Review.
Iwase S, Nishimura N, Mano T.
Muscle sympathetic nerve activity and syncope.
In: Clinical Assessment of the Autonomic Nervous System (Iwase S, Hayano J, Orimo S eds). Springer Japan, pp. 73-92, 2017. Review.
2016年
Mamun AA, Hayashi H, Sakima M, Sato Motohiko
Adenosine triphosphate is a critical determinant for VEGFR signal during hypoxia.
American Journal of Physiology - Cell Physiology 311(6): C985-C995, 2016.
Nakamura E, Kinoshita H, Feng GG, Hayashi H, Satomoto M, Sato Motoiko, Fujiwara Y.
Sevoflurane inhalation accelerates the long-term memory consolidation via small GTPase overexpression in the hippocampus of mise in adolescence.
PLoS One 11(9): e0163151, 2016.
Yasuda Y, Feng GG, Li J, Nakamura E, Hayashi H, Sato Motohiko, Fujiwara Y, Kinoshita H.
High oxygen modifies vasodilator effect of cysteine via enhanced oxidative stress and thromboxane production in the rat mesenteric artery.
Pflugers Archiv: European Journal of Physiology 468(9): 1555-64, 2016.
Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Liang C, Prajapati R, Umemura M, Yokoyama U, Sato Motohiko, Okumura S, Ishikawa Y.
Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac
dysfunction.
Biochemical and Biophysical Research Communications 475(1): 1-7, 2016.
Sato I, Umemura M, Mitsudo K, Fukumura H, Kim JH, Hoshino Y, Nakashima H, Kioi M, Nakakaji R, Sato Motohiko, Fujita T, Yokoyama U, Okumura S, Oshiro H, Eguchi H, Tohnai I, Ishikawa Y.
Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles.
Scientific Reports 6: 24629, 2016. doi: 10.1038/srep24629
Nakagaki A, Inami T, Minoura T, Baba R, Iwase S, Sato Motohiko.
Differences in autonomic neural activity during exercise between the second and third trimester of pregnancy.
Journal of Obstetrics and Gynaecology Research 42(8): 951-959, 2016.
Eckberg DL, Cooke WH, Diedrich A, Biaggioni I, Buckey JC Jr, Pawelczyk JA, Ertl AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase S, Baisch FJ, Levine BD, Adams-Huet B, Robertson D, Blomqvist CG.
Respiratory modulation of human autonomic function on Earth.
Journal of Physiology 594(19): 5611-5627, 2016.
Eckberg DL, Diedrich A, Cooke WH, Biaggioni I, Buckey JC Jr, Pawelczyk JA, Ertl AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase S, Baisch FJ, Levine BD, Adams-Huet B, Robertson D, Blomqvist CG.
Respiratory modulation of human autonomic function. Long-term neuroplasticity in space.
Journal of Physiology 594(19): 5629-5646, 2016.
Hayashi H, Mamun AA, Sakima M, Sato Motohiko.
Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing during angiogenesis.
Journal of Cell Science 129(6): 1210-1222, 2016.
Iwase S, Kawahara Y, Nishimura N, Sugenoya J.
Effect of micro mist sauna bathing on thermoregulatory and circulatory functions and thermal sensation in humans.
International Journal of Biometeorology 60(5): 699-709, 2016.
Ohno H, Nishimura N, Yamada K, Shimizu Y, Nishimura R, Iwase S, Sugenoya J, Sato Motohiko.
Water nanodroplets emitted from an air conditioner increased skin moisture levels at the lateral canthus in winter by forming a lipid film with sebum.
Skin Research and Technology 22(3): 388-390, 2016.
2015年
Imai M, Kuwahara Y, Hirai M, Nishimura R, Nishimura N, Shimizu Y, Fujii T, Iwase S.
Effects of defecation strain at various bed reclining angles on intrarectal pressure and cardiovascular responses.
Nursing Research 64(6): 413-421, 2015.
Takakura H, Furuichi Y, Yamada T, Jue T, Ojino M, Hashimoto T, Iwase S, Hojo T, Izawa T, Masuda K.
Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle.
Scientific Reports 5: 9403, 2015. doi: 10.1038/srep09403
Suita K, Fujita T, Hasegawa N, Cai W, Jin H, Hidaka Y, Prajapati R, Umemura M, Yokoyama U, Sato Motohiko, Okumura S, Ishikawa Y.
Norepinephrine-induced adrenergic activation strikingly increased the atrial fibrillation duration through β1- and α1-adrenergic receptor-mediated signaling in mice.
PLoS One 10(7): e0133664, 2015.
Onizuka C, Niimi Y, Sato Motohiko, Sugenoya J.
Arterial blood pressure response to head-up tilt test and orthostatic tolerance in nurses.
Environmental Health and Preventive Medicine 20(4): 262-270, 2015.
Eguchi H, Umemura M, Kurotani R, Fukumura H, Sato I, Kim JH, Hoshino Y, Lee J, Amemiya N, Sato Motohiko, Hirata K, Singh DJ, Masuda T, Yamamoto M, Urano T, Yoshida K, Tanigaki K, Yamamoto M, Sato M, Inoue S, Aoki I, Ishikawa Y.
A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging.
Scientific Reports 5: 9194, 2015. doi: 10.1038/srep09194
Sato Maki, Kanikowska D, Iwase S, Shimizu Y, Nishimura N, Inukai Y, Sugenoya J, Sato Motohiko.
Changes in plasma adiponectin, IL-6, TNF-α and free fatty acid concentrations in obese Japanese men.
British Journal of Medicine & Medical Research 7(2): 131-137, 2015.
Tsunematsu T, Okumura S, Motonami Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Yokoyama U, Sato Motohiko, Fujita T, Ishikawa Y.
Coupling of β1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.
Biomedical and Biophysical Research Communications 458(3): 531-535, 2015.
Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato Motohiko, Furutani K, Kitano H, Ishikawa Y.
Oscillation of cAMP and Ca2+ in cardiac myocytes: a systems biology approach.
Journal of Physiological Sciences 65(2): 195-200, 2015.
Takada M, Fukui Y, Matsuura Y, Sato Motohiko, Takada H.
Peripheral viewing during exposure to a 2D/3D video clip: effects on the human body.
Environmental Health and Preventive Medicine 20(2): 79-89, 2015.
Kuwahara Y, Tsukahara R, Iwase S, Shimizu Y, Nishimura N, Sugenoya J, Sato Motohiko.
Arousal electrical stimuli evoke sudomotor activity related to P300, and skin vasoconstrictor activity related to N140 in humans.
Clinical Neurophysiology 126(5): 933-942, 2015.
Ohshima Y, Yanagishita T, Ito K, Tamada Y, Nishimura N, Inukai Y, Iwase S, Watanabe D.
A case of acquired idiopathic generalized anhidrosis in a 2-year-old infant.
Journal of the European Academy of Dermatology and Venereology 29(7): 1446-1448, 2015.
Kanikowska D, Sato Maki, Witowski J.
Contribution of daily and seasonal biorhythms to obesity in humans.
International Journal of Biometeorology 59(4): 377-84, 2015.
Ohno H, Nishimura N, Yamada K, Shimizu Y, Nishimura R, Iwase S, Sugenoya J, Sato Motohiko.
Water nanodroplets make a greater contribution to facial skin moisture levels in air-conditioned rooms during winter than in summer.
Skin Research and Technology 21(2): 207-213, 2015.
2014年
Iwase S, Nishimura N, Mano T.
Role of sympathetic nerve activity in the process of fainting.
frontiers in Physiology 5: Article 343, 2014. Review.
Aoki R, Yokoyama U, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato Motohiko, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, Ishikawa Y.
Decreased serum osmolality promotes ductus arteriosus constriction.
Cardiovascular Research 104(2): 326-336, 2014.
Sato Motohiko, Hiraoka M, Suzuki H, Sakima M, Mamun AA, Yamane Y, Fujita T, Yokoyama U, Okumura S, Ishikawa Y.
Protection of cardiomyocytes from the hypoxia-mediated injury by a peptide targeting the activator of G-protein signaling 8.
PLoS One 9(3):e91980, 2014.
Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H-L, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato Motohiko, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y.
Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.
Journal of Clinical Investigation 124(6): 2785-2801, 2014.
Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T, Feng X, Oda K, Miyajima A, Makino A, Iwai M, Fujita T, Yokoyama U, Okumura S, Sato Motohiko, Eguchi H, Thonai I, Ishikawa Y.
Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells.
Journal of Physiological Sciences 64(3): 177-183, 2014.
Iwase S*, Inukai Y*, Nishimura N, Sato Maki, Sugenoya J. (* equally contributed)
Hemifacial hyperhidrosis associated with ipsilateral/contralateral cervical disc herniation myelopathy. Functional considerations on how compression pattern determines the laterality.
Functional Neurology 29(1): 67-73, 2014.
Iwase S, Kawahara Y, Nishimura N, Nishimura R, Sugenoya J, Miwa C, Takada M.
Effects of isotonic and isometric exercises with mist sauna bathing on cardiovascular, thermoregulatory, and metabolic functions.
International Journal of Biometeorology 58(6): 1109-1117, 2014.
Iwase S, Kawahara Y, Nishimura N, Nishimura R, Miwa C, Kataoka Y, Kobayashi C, Suzuki T, Shigaraki M, Maeda Y, Takada H, Watanabe Y.
A comparison of head-out mist bathing, with or without facial fanning, with head-out half-body low-water level bathing in humans-a pilot study.
International Journal of Biometeorology 58(5): 999-1005, 2014.
2013年
Tanaka H, Yamaguchi E, Fukuoka T, Ohbayashi Y, Sato Motohiko, Yokoi T.
A case of disseminated nontuberculous mycobacteriosis and cerebellar toxoplasmosis with autoantibody to interferon-γ.
Sarcoidosis Vasculitis and Diffuse Lung Diseases 30: 312-316, 2013.
Tanaka K, Nishimura N, Sato Maki, Kanikowska D, Shimizu Y, Inukai Y, Abe C, Iwata C, Morita H, Iwase S, Sugenoya J.
Arterial pressure oscillation and muscle sympathetic nerve activity after 20days of head-down bed rest.
Autonomic Neuroscience: Basic & Clinical 177(2): 266-270, 2013.
Shimizu Y, Matsuura Y, Yamaguchi Y, Iwase S.
Sleep-related rhythm in 6 cpm power of electrogastrogram during sleep in constipated young women.
Biological Rhythm Research 44(5): 822-829, 2013.
Ohno H, Nishimura N, Yamada K, Shimizu Y, Iwase S, Sugenoya J, Sato Motohiko.
Effects of water nanodroplets on skin moisture and viscoelasticity during air-conditioning.
Skin Research and Technology 19(4): 375-383, 2013.
Sato Motohiko.
Roles of accessory proteins for heterotrimeric G-protein in the development of cardiovascular diseases.
Circulation Journal 77(10): 2455-2461, 2013. Review.
Sato Maki, Kanikowska D, Iwase, S, Shimizu Y, Nishimura N, Inukai Y, Sato Motohiko, Sugenoya J.
Seasonal differences in melatonin concentrations and heart rates during sleep in obese subjects in Japan.
International Journal of Biometeorology 57(5): 743-748, 2013.
Kanikowska D, Sato Maki, Sugenoya J, Shimizu Y, Nishimura N, Inukai Y, Iwase S.
Attenuated thermoregulatory responses with increased plasma osmolality in obese subjects during two seasons.
International Journal of Biometeorology 57(5): 663-667, 2013.
Kanikowska D, Sato Maki, Iwase S, Shimizu Y, Nishimura N, Inukai Y, Sugenoya J.
Effects of living at two ambient temperatures on 24-h blood pressure and neuroendocrine function among obese and non-obese humans: a pilot study.
International Journal of Biometeorology 57(3): 475-481, 2013.
Iwase S, Nishimura N, Mano T.
Osteoporosis in Spaceflight.
"Topics in Osteoporosis" edited by Flores MV, InTech, pp. 259-279, 2013.
Iwase S, Kawahara Y, Nishimura N, Takada H, Nagata M, Niimi Y, Miwa C.
Effects of dry and mist saunas on circulatory and thermoregulatory functions in humans.
Health 5(2): 267-273, 2013. doi: 10.4236/health.2013.52036
Ohshima Y, Yanagishita T, Ito K, Tamada Y, Nishimura N, Inukai Y, Iwase S, Sugenoya J, Watanabe D.
Treatment of patients with acquired idiopathic generalized anhidrosis.
British Journal of Dermatology 168(2): 430-432, 2013.
Iwase S, Kawahara Y, Miwa C, Nishimura N.
Effect of efficacy of thermal environment provided by a new bathing style, "mist sauna bathing".
Balneo Research Journal 4(1), 2013. doi: 10.12680/balneo.2013.1039
2012年
Takada M, Uemoto K, Miyao M, Matsuura M, Sato Motohiko, Takada H.
Comparison of fixation distances in middle-aged subjects.
International Journal of Bioscience, Biochemistry and Bioinformatics 2(6): 389-394, 2012.
Takada M, Miyao M, Sato Motohiko, Yoshikawa K, Matsuura Y, Takada H.
Effect of accommodation training on visual function of visual inspection workers and middle-aged people.
Journal of Sports Medicine & Doping Studies 2: 112, 2012. doi: 10.4172/2161-0673.1000112.
Takada H, Taniguchi S, Shimizu Y, Hirata T.
System to control upright posture with alcoholic intake.
Journal of Mathematics and System Science 2: 447-453, 2012.
Bai Y, Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, Jin M, Cai W, Jin HL, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato Motohiko, Iwatsubo K, Ishikawa Y, Okumura S.
Pharmacological stimulation of type 5 adenylyl cyclase stabilizes heart rate under both microgravity and hypergravity induced by parabolic flight.
Journal of Pharmacological Sciences 119(4): 381-389, 2012.
Ichikawa Y, Yokoyama U, Iwamoto M, Oshikawa J, Okumura S, Sato Motohiko, Yokota S, Masuda M, Asou T, Ishikawa Y.
Inhibition of phosphodiesterase type 3 dilates the rat ductus arteriosus without inducing intimal thickening.
Circulation Journal 76(10): 2456-2464, 2012.
Yokoyama U, Ishiwata R, Jin MH, Kato Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fujita T, Okumura S, Sato Motohiko, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, Ishikawa Y.
Inhibition of EP4 signaling attenuates aortic aneurysm formation.
PLoS One 7(5):e36724, 2012.
Fukumura H, Sato Motohiko, Kezuka K, Sato I, Feng X, Okumura S, Fujita T, Yokoyama U, Eguchi H, Ishikawa Y, Saito T.
Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells.
Journal of Physiological Sciences 62(3): 251-7, 2012.
Bernjak A, Cui J, Iwase S, Mano T, Stefanovska A, Eckberg DL.
Human sympathetic outflows to skin and muscle target organs fluctuate concordantly over a wide range of time-varying frequencies.
Journal of Physiology 590: 363-375, 2012.
Kanikowska D, Sato Maki, Sugenoya J, Iwase S, Shimizu Y, Nishimura N, Inukai Y.
No effects of acclimation to heat on immune and hormonal responses to passive heating in healthy volunteers.
International Journal of Biometeorology 56: 107-112, 2012.
2011年
Sato Motohiko, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, Ishikawa Y.
Identification of transcription factor E3 (TFE3) as a receptor-independent activator of Gα16: gene regulation by nuclear Gα subunit and its activator.
Journal of Biological Chemistry 286(20): 17766-17776, 2011.
Sato Motohiko, Yokoyama U, Fujita T, Okumura S, Ishikawa Y.
The roles of cytochrome P450 in ischemic heart disease.
Current Drug Metabolism 12(6): 526-532, 2011. Review.
Yoshimoto T, Eguchi K, Sakurai H, Ohmichi Y, Hashimoto T, Ohmichi M, Morimoto A, Yamaguchi Y, Ushida T, Iwase S, Sugenoya J, Kumazawa T.
Frequency components of systolic blood pressure variability reflect vasomotor and cardiac sympathetic functions in conscious rats.
Journal of Physiological Sciences 61: 373-383, 2011.
Yamaguchi Y, Hashimoto T, Sakurai H, Yoshimoto T, Ohmichi Y, Morimoto A, Harimoto K, Ohmichi M, Eguchi K, Kumazawa T.
Low rather than high dose lipopolysaccharide ‘priming’ of muscle provides an animal model of persistent elevated mechanical sensitivity for the study of chronic pain.
European Journal of Pain 15: 724-731, 2011.
Taniguchi Y, Sugenoya J, Nishimura N, Iwase S, Matsumoto T, Shimizu Y, Inukai Y, Sato Maki.
Contribution of central versus sweat gland mechanisms to the seasonal change of sweating function in young sedentary males and females.
International Journal of Biometeorology 55: 203-212, 2011.
Sato Maki, Kanikowska D, Sugenoya J, Inukai Y, Shimizu Y, Nishimura N, Iwase S.
Effects of aging on thermoregulatory responses and hormonal changes in humans during the four seasons in Japan.
International Journal of Biometeorology 55: 229-234, 2011.
Nishimura J, Tamada Y, Iwase S, Kubo A, Watanabe D, Matsumoto Y.
A case of lung cancer with unilateral anhidrosis and contralateral hyperhidrosis as the first clinical manifestation.
Journal of American Academy of Dermatology 65: 438-440, 2011.
Yamamoto T, Matsuura Y, Takada H, Iwase S, Sugenoya J.
Electrogastrography in the elderly and effect of hot stupes on the solar plexus.
Nihon Eiseigaku Zasshi. 2011 Jan;66(1):71-6.
2010年
Sato Motohiko and Ishikawa Y.
Accessory proteins for heterotrimeric G protein: Implication in the cardiovascular system.
Pathophysiology: the official journal of the International Society for Pathophysiology 17(2): 89-99, 2010. Review.
Otsu K, Toya Y, Oshikawa J, Kurotani R, Yazawa T, Sato Motohiko, Yokoyama U, Umemura S, Minamisawa S, Okumura S, Ishikawa Y.
Caveolin gene transfer improves glucose metabolism in diabetic mice.
American Journal of Physiology: Cell Physiology 298(3): C450-C456, 2010.
Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato Motohiko, Yokota S, Hammond HK, Ishikawa Y.
Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.
Circulation Research 106(12): 1882-1892, 2010.
Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kato Y, Kurotani R, Sato Motohiko, Okumura S, Ishikawa Y.
Differential roles of Epac in regulating cell death in neuronal and myocardial cells.
Journal of Biological Chemistry 285(31): 24248-24259, 2010.
Kanikowska D, Sato Maki, Iwase S, Nishimura N, Shimizu Y, Inukai Y, Sugenoya J.
Leptin and ghrelin levels in humans during physical inactivity induced by head-down bed rest.
Aviation, Space, and Environmental Medicine 81: 383-386, 2010.
Ishida K, Katayama K, Akima H, Iwase S, Sato K, Hotta N, Miyamura M.
Effects of deconditioning on the initial ventilatory and circulatory responses at the onset of exercise in man.
Advances in Experimental Medicine and Biology 669: 319-322, 2010.
Kanikowska D, Sugenoya J, Sato Maki, Shimizu Y, Inukai Y, Nishimura N, Iwase S.
Influence of season on plasma antidiuretic hormone, angiotensin II, aldosterone and plasma renin activity in young volunteers.
International Journal of Biometeorology 54: 243-248, 2010.
Masuda K, Takakura H, Furuichi Y, Iwase S, Jue T.
NIRS measurement of O(2) dynamics in contracting blood and buffer perfused hindlimb muscle.
Advances in Experimental Medicine and Biology 662:323-328, 2010.
Takakura H, Masuda K, Hashimoto T, Iwase S, Jue T.
Quantification of myoglobin deoxygenation and intracellular partial pressure of O2 during muscle contraction during haemoglobin-free medium perfusion.
Experimental Physiology 95: 630-640, 2010.
Mano T, Nishimura N, Iwase S.
Sympathetic neural influence on bone metabolism in microgravity.
Acta Physiologica Hungarica 97: 354-61, 2010. Review.
2009年
Sato Motohiko, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, Takeya T, Minamisawa S, Lanier SM, Ishikawa Y.
Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: Role of gbetagamma and connexin43 (CX43).
Journal of Biological Chemistry 284(45): 31431-31440, 2009.
Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato Motohiko, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y, Minamisawa S.
T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation.
Journal of Biological Chemistry 284(36): 24025-24034, 2009.
Takada H, Shiozawa T, Takada M, Iwase S, Miyao M.
Evaluating indices of age-related muscle performance by using surface electromyography.
Conference Proceeding of IEEE Eng Med Biol Soc. 2009: 6271-6275, 2009.
Kanikowska D, Sugenoya J, Sato Maki, Shimizu Y, Inukai Y, Nishimura N, Iwase S.
Seasonal variation in blood concentrations of interleukin-6, adrenocorticotrophic hormone, metabolites of catecholamine and cortisol in healthy volunteers.
International Journal of Biometeorology 53: 479-485, 2009.
Kamiya A, Kawada T, Shimizu S, Iwase S, Sugimachi M, Mano T.
Slow head-up tilt causes lower activation of muscle sympathetic nerve activity: loading speed dependence of orthostatic sympathetic activation in humans.
American Journal of Physiology, Heart and Circulatory Physiology 297: H53-8, 2009.
Kurimoto F, Saito K, Watanabe T, Nagatani T, Nishiwaki K, Wakabayashi T, Iwase S.
Preliminary measurement of intraoperative sympathetic nerve activity using microneurography and laser Doppler flowmetry during surgical resection of suprasellar tumors.
Neurol Med Chir (Tokyo) 49: 13-21, 2009.
Furuichi Y, Masuda K, Takakura H, Hotta N, Ishida K, Katayama K, Iwase S, Akima H.
Effect of intensive interval training during unloading on muscle deoxygenation kinetics.
International Journal of Sports and Medicine 30: 563-8, 2009.
Sato Maki, Kanikowska D, Iwase S, Shimizu Y, Inukai Y, Nishimura N, Sugenoya J.
Effects of encouraged water drinking on thermoregulatory responses after 20 days of head-down bed rest in humans.
International Journal of Biometeorology 53: 443-449, 2009.
Sato Maki, Kanikowska D, Iwase S, Nishimura N, Shimizu Y, Belin de Chantemele E, Matsumoto T, Inukai Y, Taniguchi Y, Ogata A, Sugenoya J.
Effects of immersion in water containing high concentrations of CO2 (CO2-water) at thermoneutral on thermoregulation and heart rate variability in humans.
International Journal of Biometeorology 53: 25-30, 2009.
2008年
Okumura S, Tsunematsu T, Bai Y, Jiao Q, Ono S, Suzuki S, Kurotani R, Sato Motohiko, Minamisawa S, Umemura S, Ishikawa Y.
Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight.
Journal of Applied Physiology 105(1): 173-179, 2008.
Yokoyama U, Minamisawa S, Quan H, Akaike T, Suzuki S, Jin M, Jiao Q, Watanabe M, Otsu K, Iwasaki S, Nishimaki S, Sato Motohiko, Ishikawa Y.
PGE2-activated Epac promotes neointimal cushion formation of the rat ductus arteriosus by a process distinct from that of PKA.
Journal of Biological Chemistry 283(42): 28702-28709, 2008.
Kanikowska D, Sato Maki, Iwase S, Shimizu Y, Inukai Y, Nishimura N, Sugenoya J.
Immune and neuroendocrine responses to head-down rest and countermeasures.
Aviation, Space, and Environmental Medicine 79(12): 1091-1095, 2008.
Saito M, Iwase S, Hachiya T.
Resistance exercise training enhances sympathetic nerve activity during gatigue-inducing isometric handgrip trials.
European Journal of Applied Physiology 105: 225-234, 2008.
Kamiya A, Michikami D, Iwase S, Mano T.
Decoding rule from vasoconstrictor skin sympathetic nerve activity to nonglabrous skin blood flow in humans at normothermic rest.
Neuroscience Letters 439: 13-17, 2008.
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