Refer to JaPAN-led publications on candidate gene polymorphisms and pancreatic cancer risk in the Japanese population.
In a meta-analysis of three GWASs comprising genotype data of 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population, we identified three (13q12.2, 13q22.1, and 16p12.3) genome-wide significant loci (P<5.0×10−8) and four suggestive loci (P<1.0×10−6) for pancreatic cancer risk. The detailed results has been published in
Lin Y, Nakatochi M, Hosono Y, et al. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Nat Commun 2020;11:3175
Nakatochi M, Lin Y, Ito H, et al. Prediction model for pancreatic cancer in the general Japanese population. PLoS One 2018;13(9), e0203386
Nakao H, Wakai K, Ishii N, et al. Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects. BMC Gastroenterology 2016;16(1):83
Ueno M, Ohkawa S, Morimoto M, et al. Genome-wide association study-identified SNPs (rs5790844, rs3790843) in the NR5A2 gene and risk of pancreatic cancer in Japanese. Scientific Reports 2015;5:17018
Kuruma S, Egawa N, Kurata M, et al. Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan. World Journal of Gastroenterology 2014;20(46)17456-62.
Yamada I, Matsuyama M, Ozaka M, et al. Lack of associations between genetic polymorphisms in GSTM1, GSTT1 and GSTP1 and pancreatic cancer risk: a multi-institutional case-control study in Japan. Asian Pacific Journal of Cancer Prevention 2014;15(1):391-5.
Lin Y, Ueda J, Yagyu K, et al. Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case-control study in Japan. BMC Cancer 2013;13:337
Lin Y, Yagyu K, Egawa N, et al. An overview of genetic polymorphisms and pancreatic cancer risk in molecular epidemiologic studies. Journal of Epidemiology 2011;21(1):2-12.
Other JaPAN publications
Nakatochi M, Kanai M, Nakayama A, et al. Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid in Japanese individuals. Communication Biology 2019;2:115.
Low SK, Chin YM, Ito H, et al. Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population. Scientific Reports 2019;9(1):17332
Koyanagi YN, Ito H, Matsuo K, et al. Smoking and pancreatic cancer incidence: a pooled analysis of 10 population-based cohort studies in Japan. Cancer Epidemiology, Biomarkers, and Prevention 2019;28(8):1370-8.
Egawa N, Lin Y, Tabata T. ABO blood type, long-standing diabetes, and the risk of pancreatic cancer. World Journal of Gastroenterology 2013;19(16):2537-42