業績
本研究室は２００７年４月より教授が渡辺に代わりました。
本項では、前任の木全教授時代の２００５年以降の代表論文十報を記載します。

Watanabe H, Shionyu M, Kimura T, Kimata K, Watanabe H: Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation. J Biol Chem. 2007, in press

Kobayashi T, Habuchi H, Tamura K, Ide H, Kimata K: Essential role of heparan sulfate 2-O-sulfotransferase in chick limb bud patterning and development. J Biol Chem. 2007, in press.

Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL, Kimata K: Mice deficient in heparan sulfate 6-o-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. J Biol Chem. 2007, in press.

Sugiura N, Shimokata S, Watanabe H, Kimata K: MS analysis of chondroitin polymerization: effects of Mn2+ ions on the stability of UDP-sugars and chondroitin synthesis. Anal Biochem. 365(1):62-73.

Nagai N, Habuchi H, Kitazume S, Toyoda H, Hashimoto Y, Kimata K: Regulation of heparan sulfate 6-O-sulfation by beta-secretase activity. J Biol Chem. 2007, in press.

Sakai K, Kimata K, Sato T, Gotoh M, Narimatsu H, Shinomiya K, Watanabe H: Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage. J Biol Chem. 282, 4152-61, 2007.

Zhuo L, Kanamori A, Kannagi R, Itano N, Wu J, Hamaguchi M, Ishiguro N, Kimata K: SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum.J Biol Chem. 281, 20303-14, 2006.

Matsumoto K, Kamiya N, Suwan K, Atsumi F, Shimizu K, Shinomura T, Yamada Y, Kimata K, Watanabe H: Identification and characterization of versican/PG-M aggregates in cartilage. J Biol Chem. 281, 18257-63. 2006.

Kamiya N, Watanabe H, Habuchi H, Takagi H, Shinomura T, Shimizu K, Kimata K: Versican/PG-M regulates chondrogenesis as an extracellular matrix molecule crucial for mesenchymal condensation. J Biol Chem. 281, 2390-400, 2006.

Ashikari-Hada S, Habuchi H, Kariya Y, Kimata K: Heparin regulates vascular endothelial growth factor165-dependent mitogenic activity, tube formation, and its receptor phosphorylation of human endothelial cells. Comparison of the effects of heparin and modified heparins. J Biol Chem. 280, 31508-15, 2005.